Research Article
Facile Synthesis, Characterization, and In Vitro Antimicrobial Screening of a New Series of 2,4,6-Trisubstituted-s-triazine Based Compounds
Table 2
Zone of inhibition (mm) of the synthesized compounds.
| | Compounds | Zone of inhibition (mm)# | | Gram positive bacteria | Gram negative bacteria | Fungal strains | | B. subtilis | B. cereus | S. epidermidis | S. aureus | E. coli | K. pneumoniae | P. mirabilis | P. aeruginosa | C. albicans | C. tropicalis |
| | 4a | 18.6 | 16.5 | — | 14.0 | 16.0 | — | — | 11.8 | — | 16.0 | | 4b | — | — | 12.8 | — | — | 11.0 | — | — | — | — | | 4c | — | 14.6 | — | 16.8 | — | 18.4 | 18.4 | 17.8 | 21.8 | 19.4 | | 4d | 22.4 | 19.6 | 17.4 | 20.2 | 10.4 | — | — | — | — | — | | 4e | — | — | 14.5 | — | — | 15.4 | 16.0 | — | — | — | | 4f | — | — | — | 14.8 | | 14.8 | — | — | — | — | | 4g | 15.3 | 18.4 | — | — | 20.0 | 17.0 | 17.6 | 18.2 | 22.2 | 14.8 | | 4h | 24.3 | 20.8 | 19.6 | 22.4 | 15.6 | 14.0 | — | 15.0 | 17.0 | 15.0 | | 4i | — | 15.4 | | — | 13.5 | — | 12.0 | — | — | — | | 4j | — | 18.1 | 12.4 | — | 19.2 | — | 16.8 | — | 11.6 | 18.0 | | 4k | 11.6 | — | 10.6 | — | 20.6 | 19.6 | 17.4 | 18.8 | — | — | | 4l | — | — | 11.0 | — | — | 9.8 | 10.2 | — | 10.8 | — | | 4m | — | 17.0 | — | 18.0 | 20.0 | — | 12.0 | — | — | — | | 4n | 18.8 | 17.4 | 20.4 | 19.6 | 22.8 | 20.0 | 18.2 | 20.1 | — | 21.4 | | 4o | — | 11.4 | — | — | 13.0 | — | 11.2 | — | — | 10.2 | | Ciprofloxacin | 25.4 | 23.5 | 21.0 | 26.0 | 25.0 | 24.7 | 20.2 | 21.0 | NT | NT | | Fluconazole | NT | NT | NT | NT | NT | NT | NT | NT | 25.0 | 24.6 |
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Average of three determinations; NT: not tested; — indicates no inhibition.
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