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International Journal of Medicinal Chemistry
Table of Contents
Special Issues
International Journal of Medicinal Chemistry
/
2015
/
Article
/
Tab 1
/
Research Article
p
-Sulfonic Acid Calix[4]arene as an Efficient Catalyst for One-Pot Synthesis of Pharmaceutically Significant Coumarin Derivatives under Solvent-Free Condition
Table 1
Coumarins prepared from tetrasulfonic acid calixarene via Pechmann reaction.
Substrate
Product
Time (h)
Yield (%)
M. P. (found)
M. P. (obtained)
1
1a
24
15
79–81 [
46
]
78-79
2
2a
2.5
95
182–184 [
47
]
183–185
3
3a
4
75
241-242 [
46
]
240–242
4
4a
2.5
50
130-131 [
48
]
132
8
5a
2
90
158–160 [
47
]
158-159
6
6a
2.5
84
220–224 [
49
]
222–224
7
7a
2.5
88
234-235 [
47
]
232–234
8
8a
1.5
95
—
173–175
9
9a
4
92
153–155 [
47
]
151–154
10
10a
10
30
182-183 [
50
]
180-181
11
11a
24
—
—
—
M. P.: melting point.