Synthesis, In Vivo Anti-Inflammatory Activity, and Molecular Docking Studies of New Isatin Derivatives

Table 3

Docking scores (PLP Scores) of comparative COX-1 and COX-2 enzymes.

S. number	Compound	COX-1	COX-2
1	VIIa	−10	−65.52
2	VIIb	−8.72	−48.97
3	VIIc	−8.03	−57.27
4	VIId	−9.17	−62.02
5	VIIe	−26.79	−68.73
6	VIIf	−8.94	−58.18
7	VIIg	−11	−38.42
8	VIIh	−27.28	−43.3
9	VIIi	−10.51	−45.45
10	VIIj	−14.45	−51.83
11	Indomethacin	−18.91	−57.37
12	Celecoxib	−8.05	−65.05