Research Article
Synthesis, Anti-Inflammatory Activity, and In Silico Study of Novel Diclofenac and Isatin Conjugates
Table 1
Anti-inflammatory activity of tested compounds at a dose molecularly equivalent to 20mg/Kg Diclofenac.
| Compound | Percentage inhibition at different time intervals (inhibition ± SEM) | 1 hour | 2 hours | 3 hours | 4 hours |
| Diclofenac | 20.71 ± 8.0 | 20.34 ± 1.5 | 51.36 ± 9.7 | 47.99 ± 6.4 | M1 | 18.05 ± 2.1 | 55.90 ± 9.1 | 37.12 ± 6.4 | 41.61 ± 9.0 | M2 | 52.75 ± 1.7 | 61.32 ± 1.7 | 34.23 ± 5.0 | 29.47 ± 4.1 | M4 | 19.35 ± 1.8 | 43.13 ± 11.3 | 29.63 ± 5.3 | 50.39 ± 6.6 | M7 | 42.40 ± 8.4 | 46.76 ± 3.3 | 30.23 ± 2.4 | 54.52 ± 2.8 | M8 | 41.03 ± 8.9 | 24.91 ± 9.4 | 47.83 ± 2.1 | 60.48 ± 6.5 |
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Data analyzed by one way ANOVA followed by Dunnett’s test (n=5). P<0.05 and P<0.01. |