Crystallography and Its Impact on Carbonic Anhydrase Research

Figure 4

Active site mechanism. The surface rendition of CA II with zinc bound to active site residues H94, H96, and H119. The hydrophobic side is depicted in orange while the hydrophilic side is depicted in purple. Blue arrows depict substrate flow, CO₂, and through the hydrophobic side and proton transfer through the hydrophilic side. A cartoon depiction of α CA ping-pong mechanism.