Review Article
Crystallography and Its Impact on Carbonic Anhydrase Research
Table 1
Crystal structures of catalytically active human CA isoforms.
| | CA I | CA II | CA III | CA IV | CA VI | CA VII | CA IX | CA XII | CA XIII | CA XIV |
| Structures in PDB | 24 | 703 | 5 | 10 | 1 | 2 | 6 | 16 | 13 | 2 |
| PDB ID | 2CAB | 3KS3 | 1Z93 | 1ZNC | 3FE4 | 3MDZ | 5DVX | 1JCZ | 3D0N | 4LU3 |
| Resolution (Å) | 2.0 | 0.9 | 2.1 | 2.8 | 1.9 | 2.3 | 1.6 | 1.6 | 1.6 | 2.0 |
| Space group | P212121 | P21 | P65 | C2 | P212121 | C2221 | P212121 | C2 | P21 | P41212 |
| Cell dimensions (Å, °) | a = 81.5 b = 73.6 c = 37.1 | a = 42.3 b = 41.4 c = 72.3 β = 104.4 | a = 44.7 b = 44.7 c = 222.6 | a = 89.5 b = 47.7 c = 141.0 β = 106.3 | a = 57.7 b = 80.0 c = 133.4 | a = 69.7 b = 97.7 c = 82.4 | a = 57.9 b = 102.7 c = 109.0 | a = 146.7 b = 44.6 c = 85.2 β = 94.1 | a = 57.8 b = 58.2 c = 72.1 β = 92.4 | a = 88.6 b = 88.6 c = 108.9 |
| Oligomeric state | Monomer | Monomer | Monomer | Monomer | Monomer | Monomer | Monomer | Dimer | Monomer | Monomer |
| identity to CA II | 61 | - | 58 | 34 | 35 | 56 | 34 | 36 | 61 | 37 |
| Rmsd to CA II (Å) | 0.9 | - | 0.8 | 1.3 | 1.4 | 0.6 | 1.4 | 1.2 | 0.8 | 1.2 |
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To date, no crystal structures of CA VA, CAVB, CA X, or CA XI have been deposited in the PDB.
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