Review Article
Crystallography and Its Impact on Carbonic Anhydrase Research
Table 2
Active site residues in CA I- CA XIV.
| | CA I | CA II | CA III | CA IV | CA VA | CA VB | CA VI | CA VII | CA VIII | CA IX | CA X | CA XI | CA XII | CA XIII | CA XIV | | P00915 | P00918 | P07451 | P22748 | P35218 | Q9Y2D0 | P23280 | P43166 | P35219 | Q16790 | Q9NS85 | Q866X7 | O43570 | Q8N1Q1 | Q9ULX7 |
| 5-10 Å |
| 5 | W | W | W | W | C | C | W | W | W | W | W | W | W | W | W | 7 | Y | Y | Y | Y | W | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y | 62 | V | N | N | N | T | N | N | N | D | N | T | T | N | S | N | 64 | H | H | K | H | Y | Y | H | H | H | H | R | R | H | H | H | 65 | S | A | T | S | S | L | T | S | T | S | H | H | S | S | T | 67 | H | N | R | M | M | Q | Q | Q | Q | Q | S | S | K | N | Q | 92 | Q | Q | Q | Q | Q | Q | Q | Q | E | Q | Q | Q | Q | Q | Q | 121 | A | V | V | V | V | V | V | V | I | V | I | I | V | V | V | 141 | L | L | I | I | L | L | L | L | I | L | L | L | L | L | L | 143 | V | V | V | V | V | V | V | V | I | V | V | I | V | V | V | 198 | L | L | F | L | L | L | L | L | L | L | M | L | L | L | L | 200 | H | T | T | T | T | T | T | T | I | T | I | T | T | V | T | 207 | V | V | I | V | V | V | V | V | V | V | A | V | V | V | V | 209 | W | W | W | W | W | W | W | W | W | W | W | W | W | W | W | 244 | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N |
| 10-15 Å |
| 60 | I | L | L | Q | W | W | V | T | T | R | Y | Y | T | S | H | 69 | N | E | V | L | E | E | S | D | I | T | R | L | N | D | S | 91 | F | I | R | K | K | K | Q | K | Y | L | E | S | T | R | A | 131 | L | F | F | V | Y | F | Y | F | I | V | V | L | A | F | L | 135 | A | V | L | Q | V | A | Q | A | V | L | A | T | S | A | A | 201 | P | P | P | P | P | P | P | P | P | P | P | P | P | P | P | 202 | P | P | P | T | P | P | P | P | P | P | P | P | P | P | P | 204 | Y | L | E | D | T | S | T | S | S | A | Y | S | N | L | Y |
| 15-20 Å |
| 4 | D | H | E | H | S | T | D | G | E | H | W | W | K | S | H | 19 | L | D | L | L | P | V | H | L | V | V | V | V | K | F | S | 20 | Y | F | F | V | V | D | Y | Y | F | S | N | N | Y | F | Y | 21 | P | P | P | P | S | L | P | P | P | P | S | A | P | P | P | 22 | I | I | N | V | V | V | A | I | D | A | A | A | S | I | E | 57 | K | L | K | W | L | L | F | L | C | L | G | G | F | K | L | 58 | E | R | T | T | Y | H | P | S | E | R | T | T | L | I | D | 72 | D | D | D | N | D | D | S | D | S | P | K | P | S | D | S | 123 | W | W | W | K | W | W | Y | W | W | L | Y | F | Y | W | Y | 130 | S | D | T | N | N | N | S | T | S | R | N | N | D | S | S | 132 | A | G | K | K | K | E | D | G | D | D | T | S | S | V | S | 136 | S | Q | K | D | V | L | D | S | G | G | K | R | N | H | E | 170 | K | K | K | P | K | K | P | K | K | E | K | K | K | K | K | 171 | G | G | G | E | D | D | G | G | G | G | N | N | G | G | D | 173 | R | S | E | S | R | L | R | K | S | E | A | A | E | Q | K |
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