Figure 3: Parametric images of segmented lungs of a control mouse and K. pneumoniae-challenged mouse computed by the Patlak analysis (a). The value of a single voxel within an area of high FDG uptake (indicated by arrow) is significantly higher than the whole-lung value computed by the Patlak method (b), leading to the skewing effect observed between the apparent average lung of the slice and the whole-lung value estimated from the three-compartment model analysis.