SPECT Imaging Agents for Detecting Cerebral β-Amyloid Plaques

Table 1

Inhibition constants (𝐾_𝑖, nM)^a of compounds for the binding of ligands to aggregates of Aβ(1–40) and Aβ(1–42).

Compound	Aβ(1–40)	Aβ(1–42)
12	22.6 ± 3.4	30.0 ± 3.4
13	13.2 ± 0.2	15.6 ± 2.4
14	29.0 ± 3.2	38.3 ± 8.1
15	72.5 ± 8.2	77.2 ± 9.2
Thioflavin T	>1000	>1000
Congo Red	>1000	>1000

^aValues are the mean ± standard error of the mean for 6 independent experiments.