SPECT Imaging Agents for Detecting Cerebral β-Amyloid Plaques
Table 2
Biodistribution of radioactivity after intravenous injection of [125I]12, [125I]13, [125I]14, and [125I] 15 in normal micea.
Tissue
Time after injection (min)
2
10
30
60
[125I]12
Blood
1.89 (0.28)
1.39 (0.10)
1.34 (0.07)
1.50 (0.09)
Liver
16.28 (0.90)
25.28 (0.31)
18.61 (1.81)
15.14 (0.89)
Kidney
8.13 (1.28)
5.21 (0.44)
3.85 (0.33)
3.05 (0.25)
Intestine
3.10 (0.61)
7.91 (1.05)
12.84 (1.18)
21.48 (3.17)
Spleen
2.57 (1.54)
2.31 (0.01)
1.76 (0.23)
1.52 (0.29)
Heart
4.87 (0.66)
2.66 (0.12)
1.67 (0.14)
1.28 (0.12)
Stomachb
0.78 (0.02)
0.87 (0.22)
1.44 (0.69)
1.80 (0.84)
Brain
4.12 (0.15)
3.68 (0.18)
1.84 (0.12)
1.19 (0.04)
[125I]13
Blood
1.87 (0.18)
1.07 (0.08)
1.20 (0.15)
1.15 (0.16)
Liver
15.41 (0.98)
21.85 (2.14)
15.71 (0.96)
12.40 (2.38)
Kidney
8.33 (1.47)
4.31 (0.28)
3.40 (0.31)
2.32 (0.45)
Intestine
2.24 (0.24)
6.56 (0.83)
12.97 (1.15)
18.64 (2.05)
Spleen
2.72 (0.20)
1.92 (0.33)
1.58 (0.31)
1.18 (0.17)
Heart
5.63 (0.80)
2.47 (0.14)
1.69 (0.06)
1.07 (0.17)
Stomachb
0.73 (0.17)
0.63 (0.16)
1.17 (0.40)
1.06 (0.27)
Brain
3.22 (0.15)
3.61 (0.60)
1.89 (0.21)
0.99 (0.10)
[125I]14
Blood
1.87 (0.21)
1.19 (0.17)
0.40 (0.01)
0.23 (0.09)
Liver
8.96 (1.48)
9.01 (0.97)
3.75 (0.47)
1.88 (0.61)
Kidney
7.99 (1.08)
6.30 (1.02)
4.51 (1.59)
1.46 (1.12)
Intestine
3.52 (0.29)
14.39 (0.80)
22.51 (1.11)
30.05 (3.61)
Spleen
2.70 (0.08)
1.38 (0.37)
0.55 (0.30)
3.67 (5.89)
Heart
4.98 (0.41)
2.25 (0.40)
0.84 (0.14)
0.47 (0.22)
Stomachb
0.68 (0.06)
0.45 (0.18)
0.55 (0.33)
0.31 (0.07)
Brain
4.00 (0.18)
2.36 (0.33)
0.51 (0.07)
0.17 (0.05)
[125I]15
Blood
2.77 (0.43)
1.58 (0.18)
0.66 (0.03)
0.20 (0.02)
Liver
9.77 (1.89)
8.24 (0.50)
6.80 (0.86)
4.78 (1.09)
Kidney
14.79 (2.59)
15.11 (2.00)
6.45 (0.84)
1.66 (0.62)
Intestine
3.12 (0.37)
11.26 (0.63)
22.01 (1.34)
27.28 (0.48)
Spleen
3.92 (1.18)
1.55 (0.15)
0.56 (0.13)
0.17 (0.06)
Heart
5.51 (0.71)
1.60 (0.18)
0.53 (0.04)
0.12 (0.02)
Stomachb
0.89 (0.09)
0.59 (0.16)
1.56 (0.50)
0.81 (0.36)
Brain
3.31 (0.32)
1.90 (0.07)
0.52 (0.03)
0.08 (0.02)
aExpressed as % injected dose per gram. Each value represents the mean ± S.D. for 3−5 animals at each interval. bExpressed as % injected dose per organ.