Review Article
SPECT Imaging Agents for Detecting Cerebral β-Amyloid Plaques
Table 3
Biodistribution of radioactivity after injection of 99mTc-labeled benzofuran derivatives in normal micea.
| | Organ | | Time after injection (min) | | | 2 | 10 | 30 | 60 |
| | 99mTc-BAT-BF (27) |
| | Blood | 4.40 (0.27) | 1.96 (0.06) | 1.93 (0.26) | 2.15 (0.91) | | Liver | 21.94 (5.94) | 20.87 (1.28) | 19.65 (1.31) | 15.09 (3.83) | | Kidney | 10.28 (1.76) | 7.90 (0.40) | 4.27 (0.18) | 2.70 (0.57) | | Intestineb | 1.45 (0.18) | 3.68 (0.52) | 7.42 (1.62) | 9.02 (1.93) | | Spleen | 5.20 (1.01) | 3.09 (0.23) | 1.69 (0.21) | 1.16 (0.14) | | Lung | 26.70 (2.27) | 6.48 (1.33) | 3.51 (0.64) | 2.36 (0.48) | | Stomachb | 1.33 (0.57) | 1.90 (0.43) | 4.09 (1.37) | 4.17 (1.92) | | Pancreas | 4.14 (0.77) | 4.57 (0.24) | 2.98 (0.38) | 1.42 (0.15) | | Heart | 17.60 (2.60) | 8.29 (0.97) | 3.28 (1.35) | 1.51 (0.25) | | Brain | 1.34 (0.12) | 1.37 (0.18) | 0.94 (0.20) | 0.56 (0.07) |
| | 99mTc-MAMA-BF (28) |
| | Blood | 4.13 (0.42) | 1.78 (0.25) | 2.15 (0.12) | 2.24 (0.24) | | Liver | 20.17 (3.81) | 21.62 (2.62) | 23.32 (1.59) | 20.16 (2.13) | | Kidney | 7.37 (1.06) | 8.09 (1.16) | 5.11 (0.29) | 3.28 (0.45) | | Intestineb | 0.95 (0.22) | 2.13 (0.19) | 4.75 (0.93) | 5.73 (0.66) | | Spleen | 4.48 (0.56) | 3.69 (0.34) | 3.49 (0.61) | 2.59 (0.65) | | Lung | 24.04 (5.17) | 7.59 (2.13) | 4.24 (0.35) | 3.54 (1.26) | | Stomachb | 0.73 (0.21) | 2.35 (0.58) | 4.94 (0.57) | 2.81 (0.51) | | Pancreas | 2.70 (0.47) | 4.00 (1.28) | 5.48 (0.61) | 3.76 (0.36) | | Heart | 12.28 (2.20) | 10.48 (1.79) | 5.05 (0.90) | 2.16 (0.34) | | Brain | 0.74 (0.15) | 0.99 (0.22) | 1.23 (0.09) | 0.89 (0.08) |
|
|
aEach value represents the mean (SD) for 5 mice. Expressed as % injected dose per gram. bExpressed as % injected dose per organ.
|
