Comparison of Cannabinoid CB1 Receptor Binding in Adolescent and Adult Rats: A Positron Emission Tomography Study Using [18F]MK-9470
Figure 2
(a) In vivo PET/CT images of [18F]MK-9470 binding (%ID40–60 ± SEM) at 5 different coronal levels in the adolescent and the adult rat brain. The MRI-based atlas of the rat brain with 11 VOI is shown on the right side of the image. (b) Histograms presenting the adjusted absolute [18F]MK-9470 binding intensities (estimated marginal means of %ID40–60 ± SEM) in the adolescent compared to the adult cohort in 11 VOI. Two-way ANCOVA (age × region) controlling for weight was used to assess statistical significant differences in absolute [18F]MK-9470 binding between adulthood and adolescence. Statistical analysis revealed that there was a significant (# significant main effect) increase in CB1R absolute binding (44.4% calculated over 11 VOI) in adulthood compared to adolescence. Abbreviations: Striat: striatum; Frtl Cx: frontal cortex; Hipp: hippocampus; Thal: thalamus; Hypothal: hypothalamus; Amyg: amygdala; Sup Coll: superior colliculus; Cereb: cerebellum.
