Comparison of Cannabinoid CB1 Receptor Binding in Adolescent and Adult Rats: A Positron Emission Tomography Study Using [18F]MK-9470
Figure 3
Time-activity kinetic curves of [18F]MK-9470 expressed in %ID40–60 ± SEM in 6 volumes of interest (VOI), in the adolescent () (dotted line in red) and the adult () (plain line in blue) cohort. Note that adolescents’ kinetic curves appear higher compared to adults’ kinetic curve because values are expressed as %ID40–60 not taking into account weight as covariate. Estimated marginal means of %ID40–60 were evaluated in the ANCOVA and showed higher [18F]MK-9470 absolute binding in adults compared to adolescents.
