Comparison of Cannabinoid CB₁ Receptor Binding in Adolescent and Adult Rats: A Positron Emission Tomography Study Using [¹⁸F]MK-9470

Table 2

CB₁ receptor in vitro binding levels ([³H]CP55,940) in adolescents and adults rats.

	Adolescents	Adults	% change	𝑃 value
Striatum	34.62 ± 2.18	39.13 ± 2.38	13.0	0.117
Frontal cortex	28.12 ± 2.21	34.68 ± 2.51	23.4	0.024
Cortex	25.02 ± 2.49	31.81 ± 1.86	27.1	0.020
Hippocampus	44.51 ± 2.03	51.36 ± 2.26	15.4	0.018
Thalamus	20.90 ± 1.41	20.70 ± 1.16	−0.9	0.946
Hypothalamus	38.46 ± 1.53	41.01 ± 2.40	6.6	0.376
Amygdala	30.41 ± 2.29	35.09 ± 3.62	15.4	0.106
Superior colliculus	28.58 ± 1.12	26.16 ± 2.93	−8.5	0.400
Cerebellum	59.89 ± 1.66	68.98 ± 2.23	15.2	0.002
Midbrain	5.86 ± 0.96	6.35 ± 0.51	8.4	0.864
Pons	6.12 ± 1.50	6.70 ± 0.92	9.5	0.840

Two-way ANOVA followed by LSD post hoc test.
Data expressed as mean fmol/mg TE ± SEM; 𝑛=6 per group.