Autoradiographic Mapping of 5-HT1B/1D Binding Sites in the Rhesus Monkey Brain Using [carbonyl-¹¹C]zolmitriptan

Table 2

Displacement of [¹¹C]zolmitriptan binding in the nucleus accumbens (NcA), globus pallidus externa (GPE), substantia nigra (SN), visual cortex (VC), and frontal cortex (FC) by selective 5-hydroxytriptamine (HT)₁ receptor antagonists at 1 μM concentration. The numbers represent the percentage of receptor displacement compared to control sections.

Brain region	5-HT1A		5-HT1B		5-HT1D
	Mean	SE	Mean	SE	Mean	SE
NcA	0	16.0	44	3.0	3	1.0
GPE	0	11.5	67	1.0	12	7.5
SN	22	13.0	79	0.5	9	1.5
VC	18	11.3	73	2.0	25	12.1
FC	0	3.0	50	9.5	3	9.0

SE: standard error.