Invivo SPECT and SPECT/CT with 99mTc-MDP in C57BL/6 mice (3 hrs after injection dose 120 MBq i.v.). Note the high uptake in glenohumeral, the hip, and the femorotibial joints as shown in the whole body mouse (a). In (b) and (c), upper and lower extremities are shown where SPECT and CT images are coregistered. The whole body fused SPECT and CT is shown in (d). Images were acquired with the Inveon system (Siemens Medical Solutions) using dual detectors each mounted with a 5-pinhole collimator. The pinhole aperture size was 1.0 mm.
