Research Article

Longitudinal Evaluation of Fatty Acid Metabolism in Normal and Spontaneously Hypertensive Rat Hearts with Dynamic MicroSPECT Imaging

Figure 7

Time-activity curves for SHR A at 7 months estimated (a) without and (b) with tissue spillover correction for the blood curve. Spillover correction improves contrast between the blood input and myocardial uptake (triangles and circles, resp.), improves the fit of the compartmental model (solid line), and yields a metabolic rate estimate ( ) that nearly doubles, from 0.64 min-1 to 1.12  min-1.
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(a) Blood curve not corrected for spillover from myocardium
893129.fig.007b
(b) Result of tissue spillover correction