International Journal of Molecular Imaging / 2012 / Article / Tab 1 / Review Article
The Role of Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography in Evaluating the Response to Treatment in Patients with Multiple Myeloma Table 1 Characteristics of the studies using FDG-PET or PET/CT to monitor treatment response in multiple myeloma.
Authors Year Country Study design Diagnosis Treatment (no. of patients) No. of patients Device Posttherapy FDG-PET findings Complete remission Persistence of FDG uptake Normalization of FDG uptake Jadvar and Conti [9 ] 2002 USA Prospective MM CRT (2) CT + BMT (1) 3 PET 2 1 1 Mileshkin et al. [15 ] 2004 Australia Retrospective MM RT 6 PET 3 3 ns Bredella et al. [16 ] 2005 USA Retrospective MM CRT + BMT 3 PET 1 2 2 Zamagni et al. [10 ] 2007 Italy Prospective MM CT + BMT 23 PET/CT 8 15 12 Bartel et al. [11 ] 2009 USA Prospective MM CT 239 PET ns ns ns Kim et al. [17 ] 2009 USA Retrospective PLC RT 11 PET 4 (* ) 7 9 (** ) Dimitrakopoulou-Strauss et al. [12 ] 2009 Germany Prospective MM CT 19 PET ns ns ns Sager et al. [18 ] 2011 Turkey Retrospective MM CT 10 PET/CT 1 9 8
Zamagni et al. [13 ] 2011 Italy Prospective MM CT (85) 85 PET/CT 54 (improvement in 12) 31 ns CT + BMT (192) 192 67 (improvement in 32) 125 ns Derlin et al. [14 ] 2012 Germany Prospective MM BMT 99 PET/CT ns ns 40
Legend—ns: not specified; CT: chemotherapy; RT: radiation therapy; CRT: chemoradiation therapy; BMT: bone marrow transplantation; MM: multiple myeloma; PLC: solitary plasmacytoma; (* ): evolution to MM in 2 patients; (** ): late responses in 2 patients.