International Journal of Molecular Imaging

Review Article

PET Imaging in Recurrent Medullary Thyroid Carcinoma

Table 2

Technical aspects of the studies which used FDG-PET or PET/CT for detecting recurrent medullary thyroid carcinoma.
AuthorsStudy designDeviceInjected activityTime between tracer injection and image acquisition (min)PET acquisition protocolImage analysisReference standardSensitivity of FDG-PET or PET/CT*Specificity of FDG-PET or PET/CT*
Treglia et al. [5]Retrospective multicenterPET/CT259–407 MBq60Static acquisitionQualitativeHistology and/or clinical/imaging followup17%NC
Kauhanen et al. [6]Prospective multicenterPET/CT377 MBq60Static acquisition (3 min per bed position)Qualitative and semiquantitativeHistology and/or clinical/imaging followup53%NC
Ozkan et al. [7]Retrospective single centerPET/CT296–370 MBq60Static acquisition (4 min per bed position)Qualitative and semiquantitativeHistology and/or clinical/imaging followup93%68%
Gómez-Camarero et al. [8]Retrospective single centerPET and PET/CT333–434 MBq60Static acquisitionQualitative and semiquantitativeHistology and/or clinical/imaging followup88%85%
Jang et al. [10]Prospective single centerPET/CT370 MBq60Static acquisition (4 min per bed position)QualitativeHistology and/or clinical/imaging followup63%NC
Skoura et al. [12]Retrospective single centerPET/CT370 MBq60Static acquisition (4 min per bed position)Qualitative and semiquantitativeHistology and/or clinical/imaging followup47%NC
Marzola et al. [13]NR; multicenterPET/CT2.2 MBq/kg60Static acquisition (3 min per bed position)Qualitative and semiquantitativeHistology61%NC
Bogsrud et al. [14]Retrospective single centerPET and PET/CT740 MBq60–75Static acquisition (5 min per bed position)QualitativeHistology and/or clinical/imaging followup45%93%
Conry et al. [15]Retrospective multicenterPET/CT195–550 MBq50–75Static acquisition (1.5/5 min per bed position)Qualitative and semiquantitativeHistology and/or clinical/imaging followup78%NC
Beheshti et al. [16]Prospective single centerPET/CT370 MBq60Static acquisition (4 min per bed position)Qualitative and semiquantitativeHistology and/or clinical/imaging followup58%NC
Faggiano et al. [17]Retrospective multicenterPET222–370 MBq60–90Static acquisition (4 min per bed position)QualitativeHistology and/or clinical/imaging followup50%NC
Koopmans et al. [18]Prospective single centerPETNRNRStatic acquisition(5 min per bed position)QualitativeHistology and/or clinical/imaging followup24%NC
Rubello et al. [19]Prospective multicenterPET/CT5.5 MBq/kg60–90Static acquisition (4 min per bed position)Qualitative and semiquantitativeHistology79%100%
Oudoux et al. [20]Prospective multicenterPET/CT310–450 MBq60Static acquisitionQualitative and semiquantitativeHistology and/or clinical/imaging followup76%NC
Giraudet et al. [21]Prospective single centerPET/CT5 MBq/Kg60Static acquisitionQualitative and semiquantitativeHistology and/or clinical/imaging followup32%NC
Czepczyński et al. [22]NR; single centerPETNRNRStatic acquisitionQualitativeHistology and/or clinical/imaging followup58%NC
Beuthien-Baumann et al. [23]Retrospective single centerPET370 MBq60Static acquisitionQualitativeHistology and/or clinical/imaging followup47%NC
Ong et al. [24]Retrospective single centerPET and PET/CT555 MBqMinimum 45Static acquisition (4 min per bed position)Qualitative and semiquantitativeHistology and/or clinical/imaging followup62%NC
Iagaru et al. [25]Retrospective single centerPET and PET/CT550 MBq45/60Static acquisition (4/5 min per bed position)QualitativeHistology and/or clinical/imaging followup86%83%
Gotthardt et al. [26]NR; multicenterPET350 MBq60Static acquisitionQualitativeHistology and/or clinical/imaging followup70%NC
De Groot et al. [27]Prospective single centerPET400 MBq90Static acquisition (5 min per bed position)QualitativeHistology and/or clinical/imaging followup41%NC
Szakáll et al. [28]Retrospective single centerPET5.55 MBq/Kg40Static acquisition (10 min per bed position)QualitativeHistology and/or clinical/imaging followup95%NC
Diehl et al. [29]Retrospective multicenterPET300–500 MBqMinimum 30Static acquisitionQualitativeHistology and/or clinical/imaging followup78%79%
Hoegerle et al. [30]Prospective single centerPET330 MBq90Static acquisitionQualitativeHistology and/or clinical/imaging followup60%100%
Brandt-Mainz et al. [31]Prospective single centerPET350 MBq30Static acquisition (15–20 min per bed position)QualitativeHistology and/or clinical/imaging followup76%NC
Adams et al. [32]Prospective single centerPET374 MBq60Static acquisition (12–15 min per bed position)QualitativeHistology and/or clinical/imaging followup87%NC
Musholt et al. [33]NR; single centerPET370–555 MBq40Static acquisition (10 min per bed position)QualitativeHistology and/or clinical/imaging followup90%NC
NR: not reported; NC: not calculated; *sensitivity and specificity are reported on a per patient-based analysis.