817682.fig.007
Figure 7: Chemical structures of radiolabeled hypoxia imaging agents. 18F-fluoroazomycin arabinoside ([18F]FAZA) [13], 18F-fluoroerythronitroimidazole ([18F]FETNIM) [14], 123I-iodoazomycin arabinoside ([123I]IAZA) [15], 1-18F-fluoro-3-(2-nitro-1H-imidazol-1-yl)propan-2-ol ([18F]FMISO) [16], 2-18F-2-[2-nitro-1H-imidazol-1-yl]-N-(2,2,3,3,3-pentafluoropropyl)acetamide ([18F]EF5) [17], 64Cu-diacetyl-bis (4N-methylthiosemicarbazone) (64Cu-ATSM) [18], 68Ga-NOTA-nitroimidazole (68Ga-NOTA-NI) [19], 68Ga-DOTA-nitroimidazole (68Ga-DOTA-NI) [19], 68Ga-NOTA-SCN-nitroimidazole (68Ga-NOTA-SCN-NI) [20], and 68Ga-DOTA-nitroimidazole (68Ga-DOTA-SCN-NI) [20].