⁶⁸Ga-NOTA-CHSg and ^99mTc-CHSg Labeled Microspheres for Lung Perfusion and Liver Radiomicrospheres Therapy Planning

Table 1

Biodistribution for ^99mTc-CHSg and ⁶⁸Ga-NOTA-CHSg at 2 and 4 hours and ⁶⁸Ga-CHsg at 2 hours expressed as percent of decay corrected injected dose per organ (% DC-ID/organ).

Organs	Biodistribution in % DC-ID/organ
	^68Ga-NOTA-CHSg		^99mTc-CHSg		^68Ga-CHSg	Free ^68Ga
	2 hours	4 hours	2 hours	4 hours	2 hours	2 hours
Spleen	0.1±0.0	0.1±0.0	0.0±0.0	0.1±0.0	0.9±0.2	0.6±0.5
Blood	𝟎.𝟏±𝟎.𝟏	𝟎.𝟓±𝟎.𝟏	𝟎.𝟕±𝟎.𝟓	𝟎.𝟖±𝟎.𝟏	𝟒𝟔.𝟕±𝟏.𝟐	𝟖𝟒.𝟗±𝟒.𝟓
Rib	0.0±0.0	0.0±0.0	0.0±0.0	0.0±0.0	0.4±0.0	0.5±0.4
Urine	0.5±0.4	3.5±0.6	4.9±2.5	10.0±2.1	10.9±0.1	6.8±2.9
Right kidney	0.1±0.0	0.1±0.0	1.1±1.0	2.6±0.8	0.9±0.2	0.5±0.5
Left kidney	0.1±0.0	0.1±0.0	1.2±1.1	2.6±0.8	0.8±0.3	0.5±0.5
Heart	0.0±0.0	0.0±0.0	0.0±0.0	0.0±0.0	1.2±0.2	0.7±0.7
Total lungs	𝟗𝟖.𝟗±𝟎.𝟐	𝟗𝟓.𝟔±𝟎.𝟗	𝟗𝟏.𝟔±𝟔.𝟓	𝟖𝟑.𝟐±𝟒.𝟏	𝟑𝟏.𝟗±𝟏.𝟑	𝟑.𝟏±𝟐.𝟗
Total liver	0.2±0.1	0.2±0.1	0.3±0.3	0.7±0.3	6.3±0.7	2.3±1.9

Bold highlights the most important target organs. It is necessary to keep most of the activity in the lungs while the blood stays clear.