International Journal of Microbiology

Research Article

Temporal Variations among Invasive Pneumococcal Disease Serotypes in Children and Adults in Germany (1992–2008)

Table 1

(a) Serotype distribution of IPD in Germany (1992–2008, 9,394) in all age groups.


Sero- type	1992 (%)	1993 (%)	1994 (%)	1995 (%)	1996 (%)	1997 (%)	1998 (%)	1999 (%)	2000 (%)	2001 (%)	2002 (%)	2003 (%)	2004 (%)	2005 (%)	2006 (%)	2007 (%)	2008 (%)	Total (%)	Total ()

14	8.8	12.6	7.4	8.5	13.5	16.5	17.5	29.8	33.5	25.2	21.3	22.8	23.0	18.8	19.3	13.3	8.9	16.5	1,549
3	7.1	2.9	3.7	6.0	9.4	4.2	2.7	4.3	2.8	4.0	6.6	6.7	4.9	7.5	6.4	10.5	11.7	8.0	755
7F	6.7	2.9	4.9	4.3	5.2	7.5	2.7	2.1	4.3	3.7	5.8	7.3	9.0	6.4	8.0	8.7	10.4	7.6	718
1	7.5	5.8	1.2	4.3	3.1	9.4	5.8	5.5	6.7	6.4	4.3	5.3	6.9	6.9	7.9	8.5	8.8	7.3	690
23F	8.3	9.7	6.2	8.5	9.4	6.1	8.5	8.9	6.3	7.7	8.5	5.1	4.9	6.9	6.8	4.9	4.3	6.0	559
4	7.5	11.7	4.9	5.1	2.1	5.2	7.2	3.4	3.9	3.5	4.3	7.5	4.9	6.0	6.2	5.6	4.6	5.4	507
6B	3.3	7.8	7.4	6.8	6.3	8.0	5.8	6.8	3.1	7.7	6.8	5.7	5.2	7.1	4.8	3.7	2.5	4.8	449
19F	6.7	1.9	9.9	6.8	3.1	5.2	4.9	7.7	7.1	6.9	5.2	3.8	5.4	5.4	4.5	4.5	3.4	4.8	447
9V	4.2	1.0	8.6	6.0	8.3	2.8	3.1	6.4	5.5	2.2	3.3	5.3	5.6	4.8	5.1	5.1	3.6	4.5	425
6A	6.7	5.8	4.9	8.5	3.1	5.2	5.4	2.6	4.3	3.5	3.5	4.6	3.9	2.8	3.1	4.9	4.6	4.3	401
18C	4.6	4.9	6.2	1.7	1.0	6.6	6.7	3.8	7.5	4.5	4.3	2.9	3.6	3.4	3.6	2.3	3.0	3.5	326
19A	0.8	2.9	1.2	1.7	5.2	2.4	5.8	3.4	4.3	3.0	1.4	1.6	2.6	2.9	4.3	4.0	4.2	3.4	320
22F	1.3	2.9	3.7	0.0	2.1	0.5	0.9	0.0	0.0	0.7	1.0	1.0	1.5	3.0	3.0	2.9	3.0	2.2	208
8	2.1	1.9	0.0	0.9	2.1	0.5	0.9	0.0	0.4	1.5	2.3	2.1	2.1	2.5	2.2	2.5	3.0	2.2	208
10A	1.7	1.0	3.7	2.6	2.1	1.4	1.3	0.9	1.6	1.7	2.5	0.6	2.2	1.5	1.9	1.9	2.2	1.8	172
9N	2.1	1.0	1.2	3.4	1.0	1.4	0.9	1.3	1.6	1.2	1.7	1.3	1.3	1.4	1.6	2.0	2.6	1.8	172
11A	2.5	1.9	1.2	1.7	4.2	1.4	0.4	0.9	0.0	0.2	0.6	1.8	1.5	1.3	1.1	1.7	2.5	1.6	149
12F	2.5	1.9	2.5	1.7	6.3	1.4	1.3	1.3	0.0	2.2	1.0	1.8	0.7	0.4	0.4	1.0	1.7	1.3	118
24F	2.1	1.0	1.2	0.9	1.0	0.5	1.8	1.3	0.8	2.0	0.6	1.3	1.5	0.7	1.2	0.9	1.8	1.2	116
23A	0.8	1.0	1.2	0.0	0.0	0.9	1.3	0.0	0.8	0.5	0.8	0.8	0.2	0.4	0.8	1.0	1.7	0.9	88
15B	0.8	1.9	0.0	0.0	1.0	0.0	0.9	0.9	1.2	0.0	0.6	0.3	0.9	1.1	0.9	1.0	1.2	0.9	83
35F	0.8	0.0	1.2	0.9	0.0	0.5	0.4	0.9	0.8	0.5	0.0	0.3	0.0	0.4	0.5	0.7	1.8	0.8	74
33F	1.3	1.0	1.2	0.9	0.0	0.9	1.8	0.9	0.0	0.5	0.6	1.0	0.9	0.7	0.2	0.6	0.9	0.7	68
38	0.4	0.0	2.5	0.0	0.0	0.9	0.4	0.0	0.4	0.5	0.6	0.6	0.7	0.2	0.3	0.4	1.4	0.6	61
5	1.3	0.0	2.5	0.9	2.1	1.4	0.9	0.9	0.0	0.2	0.8	0.2	0.4	0.4	0.5	0.4	0.7	0.6	55
15C	1.7	0.0	0.0	1.7	0.0	3.8	0.0	0.0	0.4	0.0	0.4	0.6	0.4	0.6	0.9	0.5	0.3	0.6	53
15A	0.0	0.0	0.0	1.7	0.0	0.0	1.8	1.7	0.0	0.7	1.2	0.8	0.7	0.6	0.5	0.1	0.4	0.5	48
9A	0.4	1.0	1.2	0.9	2.1	0.9	0.9	0.0	0.8	3.5	2.1	0.6	0.0	0.4	0.0	0.2	0.0	0.5	47
20	0.8	1.9	2.5	0.0	0.0	0.0	0.0	0.4	0.0	0.0	0.0	0.6	0.6	0.8	0.3	0.6	0.4	0.5	43
NT	0.0	0.0	0.0	0.0	1.0	0.0	0.0	0.4	0.0	0.2	0.2	0.0	0.7	0.4	0.3	0.7	0.5	0.4	40
17F	0.0	1.9	0.0	0.9	0.0	0.0	0.9	0.0	0.0	0.0	1.2	0.3	0.7	0.8	0.3	0.4	0.2	0.4	39
16F	0.0	0.0	0.0	1.7	1.0	0.5	0.0	0.4	0.0	1.0	0.6	0.5	0.4	0.2	0.4	0.1	0.4	0.4	34
33A	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.4	0.8	0.8	0.5	0.2	0.3	30
31	0.8	0.0	1.2	0.9	0.0	0.0	0.0	0.0	0.0	0.5	0.4	0.5	0.0	0.1	0.3	0.1	0.5	0.3	26
18A	0.0	0.0	1.2	0.0	0.0	0.0	0.0	0.0	0.0	0.5	0.4	0.6	0.2	0.2	0.1	0.3	0.2	0.2	22
34	0.8	0.0	0.0	0.0	0.0	0.0	0.4	0.0	0.0	0.0	0.4	0.3	0.2	0.2	0.2	0.3	0.2	0.2	22
rough	0.0	1.0	1.2	0.9	1.0	0.0	0.0	0.0	0.4	0.5	1.0	1.3	0.0	0.0	0.0	0.0	0.0	0.2	20
23B	0.0	1.0	0.0	0.0	0.0	0.5	0.4	0.0	0.0	0.5	0.0	0.2	0.4	0.1	0.1	0.1	0.2	0.2	17
9L	0.0	0.0	0.0	0.0	0.0	0.0	0.4	0.0	0.0	0.7	0.8	0.3	0.2	0.0	0.2	0.2	0.0	0.2	17
13	0.0	2.9	0.0	0.0	0.0	0.9	0.0	0.0	0.0	0.2	0.6	0.0	0.2	0.0	0.0	0.1	0.1	0.2	15
18F	0.4	1.9	0.0	0.9	0.0	0.5	0.0	0.9	0.0	0.0	0.2	0.2	0.0	0.1	0.0	0.3	0.0	0.2	15
2	0.4	1.0	1.2	0.9	0.0	0.5	0.0	0.4	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.4	0.0	0.1	13
12A	0.0	0.0	0.0	0.0	0.0	0.5	0.0	0.4	0.0	0.0	0.2	0.0	0.2	0.0	0.3	0.2	0.0	0.1	12
28A	0.0	0.0	0.0	0.0	0.0	0.5	0.0	0.0	0.4	0.0	0.4	0.2	0.0	0.1	0.1	0.2	0.0	0.1	12
35B	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.2	0.0	0.2	0.0	0.0	0.2	0.2	0.1	11
10B	0.0	0.0	0.0	0.0	0.0	0.0	0.4	0.0	0.0	0.0	0.0	0.0	0.2	0.2	0.0	0.2	0.1	0.1	10
Others	2.9	1.9	2.5	7.7	3.1	0.5	4.9	1.7	1.2	1.5	0.6	1.6	0.6	1.3	0.3	1.7	0.9	1.4	130
Total	100	100	100	100	100	100	100	100	100	100	100	100	100	100	100	100	100	100	9,394

Not sero- typed	52.5	77.8	76.0	67.0	67.7	40.8	40.5	43.9	38.2	39.4	29.9	21.5	19.1	1.5	0.0	0.1	0.0	22.6	2,743

NT: nontypeable; : number of isolates tested.
Others includes the serotypes (number of isolates): 15F (9), 18B (9), 12B (8), 7C (8), 33B (7), 10F (6), 11B (6), 11F (6), 35A (6), 19C (5), 29 (5), 37 (5), 21 (4), 24A (4), 28F (4), 35C (4), 19B (3), 22A (3), 36 (3), 45 (3), 7A (3), 24B (2), 25F (2), 39 (2), 48 (2), 6 (2), 7B (2), 12 (1), 17A (1), 18 (1), 19 (1), 23 (1), 35 (1), 9 (1).

(b) Serotype distribution of IPD in Germany (1992–2008, = 2,948) in children (16 years).


Sero-type	1992 (%)	1993 (%)	1994 (%)	1995 (%)	1996 (%)	1997 (%)	1998 (%)	1999 (%)	2000 (%)	2001 (%)	2002 (%)	2003 (%)	2004 (%)	2005 (%)	2006 (%)	2007 (%)	2008 (%)	Total (%)	Total ()

14	12.8	6.9	14.3	5.9	16.7	15.2	18.0	26.9	31.5	25.5	26.7	27.0	30.6	26.3	25.4	13.9	5.6	22.5	664
1	2.1	3.4	3.6	0.0	0.0	9.5	5.6	6.6	8.0	8.4	5.4	4.5	6.0	7.6	10.5	12.5	12.9	7.9	234
6B	6.4	13.8	0.0	11.8	8.3	8.9	6.2	7.7	3.5	7.5	8.9	7.8	7.2	10.8	6.6	7.0	4.3	7.3	216
19F	8.5	3.4	7.1	23.5	0.0	6.3	6.8	8.8	8.0	9.6	5.4	5.7	6.8	7.3	8.0	8.4	4.7	7.2	213
23F	10.6	3.4	7.1	11.8	16.7	7.0	7.5	8.2	5.5	7.9	10.5	6.1	4.9	6.6	8.7	6.2	2.6	6.9	204
7F	2.1	3.4	0.0	5.9	0.0	7.6	3.7	2.2	5.5	4.6	5.8	8.6	7.9	6.0	7.7	9.9	13.8	6.9	204
18C	8.5	10.3	17.9	0.0	0.0	8.9	8.7	4.9	8.0	6.3	5.8	5.7	3.8	5.4	6.6	5.1	5.6	6.2	182
6A	14.9	20.7	3.6	5.9	0.0	5.1	5.6	2.7	4.5	3.8	4.7	4.9	3.8	3.5	1.4	4.8	5.6	4.4	130
9V	4.3	3.4	14.3	11.8	8.3	2.5	2.5	7.1	4.0	2.1	2.3	4.1	4.2	5.1	3.1	3.3	1.3	3.7	108
4	6.4	10.3	7.1	11.8	8.3	5.1	7.5	3.8	4.0	2.1	3.5	3.7	3.0	2.8	3.1	2.2	0.4	3.5	102
3	4.3	3.4	3.6	5.9	0.0	3.8	1.9	3.8	3.0	2.9	3.1	3.3	1.5	1.9	2.4	5.9	5.6	3.3	96
19A	0.0	3.4	0.0	0.0	8.3	1.9	6.2	2.2	3.5	2.5	1.6	2.0	3.0	2.5	3.8	4.0	4.7	3.1	90
10A	2.1	0.0	0.0	0.0	0.0	0.6	0.0	1.1	1.5	2.1	1.6	0.4	2.3	1.9	2.8	2.2	3.4	1.7	51
24F	4.3	3.4	0.0	0.0	0.0	0.0	2.5	1.6	1.0	2.1	0.8	2.5	1.9	0.6	1.4	1.1	2.2	1.5	44
15B	0.0	0.0	0.0	0.0	0.0	0.0	0.6	1.1	1.0	0.0	0.4	0.4	0.8	1.3	0.7	2.2	2.2	0.9	26
15C	2.1	0.0	0.0	0.0	0.0	4.4	0.0	0.0	0.0	0.0	0.4	0.8	0.4	1.3	1.4	0.4	2.2	0.9	26
9N	0.0	0.0	0.0	0.0	0.0	0.0	0.6	1.1	1.5	0.8	0.4	1.6	1.5	0.3	1.0	0.4	1.7	0.9	26
38	2.1	0.0	3.6	0.0	0.0	0.6	0.6	0.0	0.5	0.4	0.8	0.4	0.8	0.3	0.0	0.7	3.9	0.8	23
15A	0.0	0.0	0.0	0.0	0.0	0.0	1.2	1.6	0.0	0.4	1.2	1.6	0.8	0.6	1.0	0.0	0.4	0.7	21
22F	0.0	0.0	7.1	0.0	0.0	0.6	0.6	0.0	0.0	0.8	1.2	1.2	0.8	0.6	0.3	0.4	1.3	0.7	21
9A	0.0	0.0	0.0	0.0	0.0	1.3	0.6	0.0	1.0	3.8	1.9	0.8	0.0	0.0	0.0	0.0	0.0	0.7	21
5	0.0	0.0	3.6	0.0	8.3	1.9	1.2	1.1	0.0	0.0	0.8	0.0	0.8	0.9	0.3	0.0	0.9	0.6	19
8	0.0	0.0	0.0	0.0	0.0	0.6	1.2	0.0	0.5	0.4	1.2	0.4	0.8	0.9	0.7	0.4	0.4	0.6	18
33F	0.0	0.0	0.0	0.0	0.0	1.3	1.9	0.5	0.0	0.4	1.2	0.8	0.4	0.0	0.0	0.4	1.3	0.6	17
12F	2.1	0.0	3.6	0.0	0.0	0.0	0.6	1.1	0.0	1.7	0.0	0.0	0.8	0.0	0.0	0.4	1.7	0.5	16
11A	0.0	0.0	0.0	0.0	8.3	1.9	0.0	0.5	0.0	0.0	0.4	1.2	0.0	0.0	0.3	1.1	0.9	0.5	15
23A	2.1	0.0	0.0	0.0	0.0	0.6	1.2	0.0	0.5	0.0	0.4	0.4	0.0	0.0	0.7	0.4	1.7	0.5	14
18A	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.8	0.8	0.8	0.4	0.0	0.0	0.4	0.9	0.3	10
35F	0.0	0.0	0.0	0.0	0.0	0.0	0.6	0.5	1.0	0.0	0.0	0.0	0.0	0.3	0.3	0.4	1.3	0.3	10
NT	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.5	0.0	0.0	0.0	0.0	1.5	0.3	0.0	0.7	0.9	0.3	10
33A	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.4	1.3	0.7	0.4	0.4	0.3	9
rough	0.0	3.4	0.0	0.0	0.0	0.0	0.0	0.0	0.5	0.8	0.8	1.2	0.0	0.0	0.0	0.0	0.0	0.3	9
17F	0.0	0.0	0.0	0.0	0.0	0.0	1.2	0.0	0.0	0.0	0.0	0.0	0.8	0.3	0.0	0.4	0.9	0.3	8
16F	0.0	0.0	0.0	0.0	0.0	0.6	0.0	0.0	0.0	0.8	0.4	0.0	0.0	0.3	0.0	0.0	0.9	0.2	7
18B	0.0	0.0	0.0	0.0	8.3	0.0	1.2	0.5	0.5	0.0	0.0	0.0	0.0	0.6	0.0	0.0	0.0	0.2	7
23B	0.0	3.4	0.0	0.0	0.0	0.6	0.6	0.0	0.0	0.0	0.0	0.4	0.4	0.0	0.0	0.0	0.4	0.2	6
34	2.1	0.0	0.0	0.0	0.0	0.0	0.6	0.0	0.0	0.0	0.0	0.0	0.4	0.3	0.0	0.7	0.0	0.2	6
18F	0.0	0.0	0.0	0.0	0.0	0.6	0.0	1.1	0.0	0.0	0.4	0.0	0.0	0.0	0.0	0.4	0.0	0.2	5
20	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.5	0.0	0.0	0.0	0.4	0.4	0.3	0.0	0.4	0.0	0.2	5
9L	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.4	0.8	0.4	0.0	0.0	0.3	0.0	0.0	0.2	5
Others	2.1	3.4	3.6	5.9	8.3	2.5	2.5	1.6	1.5	0.8	0.8	0.4	1.5	1.6	0.3	3.3	3.0	1.7	50
Total	100	100	100	100	100	100	100	100	100	100	100	100	100	100	100	100	100	100	2,948

Not sero- typed	7.8	17.1	3.4	34.6	61.3	7.1	2.4	3.2	3.8	0.0	0.4	0.8	0.0	0.0	0.0	0.0	0.0	2.4	72

NT: nontypeable; : number of isolates tested.
Others includes the serotypes (number of isolates): 28A (4), 11B (3), 12A (3), 12B (3), 13 (3), 33B (3), 35B (3), 15F (2), 19C (2), 21 (2), 24A (2), 28F (2), 29 (2), 35A (2), 37 (2), 7A (2), 10F (1), 19B (1), 2 (1), 31 (1), 35 (1), 35C (1), 36 (1), 39 (1), 6 (1), 7C (1).

(c) Serotype distribution of IPD in Germany (1992–2008, = 6,446) in adults (16 years).


Sero-type	1992 (%)	1993 (%)	1994 (%)	1995 (%)	1996 (%)	1997 (%)	1998 (%)	1999 (%)	2000 (%)	2001 (%)	2002 (%)	2003 (%)	2004 (%)	2005 (%)	2006 (%)	2007 (%)	2008 (%)	Total (%)	Total ()

14	7.8	14.9	3.8	9.0	13.1	20.4	16.1	39.6	40.7	24.8	15.1	20.1	15.6	14.8	16.6	13.2	9.4	13.7	885
3	7.8	2.7	3.8	6.0	10.7	5.6	4.8	5.7	1.9	5.5	10.7	8.9	8.1	10.5	8.3	11.2	12.5	10.2	659
7F	7.8	2.7	7.5	4.0	6.0	7.4	0.0	1.9	0.0	2.4	5.8	6.5	10.0	6.6	8.1	8.5	9.9	8.0	514
1	8.8	6.8	0.0	5.0	3.6	9.3	6.5	1.9	1.9	3.6	3.1	5.7	7.8	6.5	6.7	7.8	8.3	7.1	456
4	7.8	12.2	3.8	4.0	1.2	5.6	6.5	1.9	3.7	5.5	5.3	9.9	6.7	7.7	7.6	6.1	5.2	6.3	405
23F	7.8	12.2	5.7	8.0	8.3	3.7	11.3	11.3	9.3	7.3	6.2	4.4	4.8	7.0	5.9	4.7	4.5	5.5	355
9V	4.1	0.0	5.7	5.0	8.3	3.7	4.8	3.8	11.1	2.4	4.4	6.0	7.0	4.6	6.1	5.4	3.9	4.9	317
6A	4.7	0.0	5.7	9.0	3.6	5.6	4.8	1.9	3.7	3.0	2.2	4.4	4.1	2.4	3.8	4.9	4.5	4.2	271
19F	6.2	1.4	11.3	4.0	3.6	1.9	0.0	3.8	3.7	3.0	4.9	2.6	4.1	4.4	2.9	3.8	3.3	3.6	234
6B	2.6	5.4	11.3	6.0	6.0	5.6	4.8	3.8	1.9	7.9	4.4	4.4	3.3	5.1	4.0	3.2	2.3	3.6	233
19A	1.0	2.7	1.9	2.0	4.8	3.7	4.8	7.5	7.4	3.6	1.3	1.3	2.2	3.1	4.5	4.0	4.1	3.6	230
8	2.6	2.7	0.0	1.0	2.4	0.0	0.0	0.0	0.0	3.0	3.6	3.1	3.3	3.4	2.9	2.8	3.4	2.9	190
22F	1.6	4.1	1.9	0.0	2.4	0.0	1.6	0.0	0.0	0.6	0.9	0.8	2.2	4.3	4.1	3.3	3.3	2.9	187
9N	2.6	1.4	1.9	4.0	1.2	5.6	1.6	1.9	1.9	1.8	3.1	1.0	1.1	2.0	1.9	2.3	2.7	2.3	146
18C	3.6	2.7	0.0	2.0	1.2	0.0	1.6	0.0	5.6	1.8	2.7	1.0	3.3	2.4	2.2	1.8	2.7	2.2	144
11A	3.1	2.7	1.9	2.0	3.6	0.0	1.6	1.9	0.0	0.6	0.9	2.1	3.0	2.0	1.4	1.8	2.7	2.1	134
10A	1.6	1.4	5.7	3.0	2.4	3.7	4.8	0.0	1.9	1.2	3.6	0.8	2.2	1.4	1.4	1.8	2.0	1.9	121
12F	2.6	2.7	1.9	2.0	7.1	5.6	3.2	1.9	0.0	3.0	2.2	2.9	0.7	0.7	0.6	1.1	1.7	1.6	102
23A	0.5	1.4	1.9	0.0	0.0	1.9	1.6	0.0	1.9	1.2	1.3	1.0	0.4	0.7	0.8	1.1	1.7	1.1	74
24F	1.6	0.0	1.9	1.0	1.2	1.9	0.0	0.0	0.0	1.8	0.4	0.5	1.1	0.7	1.1	0.8	1.7	1.1	72
35F	1.0	0.0	1.9	1.0	0.0	1.9	0.0	1.9	0.0	1.2	0.0	0.5	0.0	0.5	0.6	0.8	1.9	1.0	64
15B	1.0	2.7	0.0	0.0	1.2	0.0	1.6	0.0	1.9	0.0	0.9	0.3	1.1	1.0	1.0	0.8	1.1	0.9	57
33F	1.6	1.4	1.9	1.0	0.0	0.0	1.6	1.9	0.0	0.6	0.0	1.0	1.5	1.0	0.3	0.6	0.9	0.8	51
20	1.0	2.7	3.8	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.8	0.7	1.0	0.5	0.6	0.4	0.6	38
38	0.0	0.0	1.9	0.0	0.0	1.9	0.0	0.0	0.0	0.6	0.4	0.8	0.7	0.2	0.5	0.3	1.1	0.6	38
5	1.6	0.0	1.9	1.0	1.2	0.0	0.0	0.0	0.0	0.6	0.9	0.3	0.0	0.2	0.6	0.5	0.7	0.6	36
17F	0.0	2.7	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	2.7	0.5	0.7	1.0	0.5	0.4	0.2	0.5	31
NT	0.0	0.0	0.0	0.0	1.2	0.0	0.0	0.0	0.0	0.6	0.4	0.0	0.0	0.5	0.5	0.7	0.5	0.5	30
15A	0.0	0.0	0.0	2.0	0.0	0.0	3.2	1.9	0.0	1.2	1.3	0.3	0.7	0.5	0.3	0.1	0.4	0.4	27
15C	1.6	0.0	0.0	2.0	0.0	1.9	0.0	0.0	1.9	0.0	0.4	0.5	0.4	0.2	0.6	0.5	0.1	0.4	27
16F	0.0	0.0	0.0	2.0	1.2	0.0	0.0	1.9	0.0	1.2	0.9	0.8	0.7	0.2	0.6	0.1	0.4	0.4	27
9A	0.5	1.4	1.9	1.0	2.4	0.0	1.6	0.0	0.0	3.0	2.2	0.5	0.0	0.7	0.0	0.2	0.0	0.4	26
31	1.0	0.0	1.9	1.0	0.0	0.0	0.0	0.0	0.0	1.2	0.9	0.8	0.0	0.2	0.5	0.1	0.5	0.4	25
33A	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.4	0.5	0.8	0.5	0.2	0.3	21
34	0.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.9	0.5	0.0	0.2	0.3	0.2	0.2	0.2	16
13	0.0	4.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.6	1.3	0.0	0.4	0.0	0.0	0.1	0.2	0.2	12
18A	0.0	0.0	1.9	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.5	0.0	0.3	0.2	0.2	0.1	0.2	12
2	0.5	0.0	1.9	1.0	0.0	1.9	0.0	1.9	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.4	0.0	0.2	12
9L	0.0	0.0	0.0	0.0	0.0	0.0	1.6	0.0	0.0	1.2	0.9	0.3	0.4	0.0	0.2	0.2	0.0	0.2	12
23B	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.2	0.0	0.0	0.4	0.2	0.2	0.1	0.2	0.2	11
rough	0.0	0.0	1.9	1.0	1.2	0.0	0.0	0.0	0.0	0.0	1.3	1.3	0.0	0.0	0.0	0.0	0.0	0.2	11
10B	0.0	0.0	0.0	0.0	0.0	0.0	1.6	0.0	0.0	0.0	0.0	0.0	0.4	0.3	0.0	0.2	0.2	0.2	10
18F	0.5	2.7	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.3	0.0	0.2	0.0	0.2	0.0	0.2	10
12A	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.4	0.0	0.0	0.0	0.5	0.2	0.1	0.1	9
28A	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.9	0.3	0.0	0.0	0.2	0.2	0.0	0.1	8
35B	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.2	0.2	0.1	8
15F	0.5	0.0	0.0	1.0	0.0	0.0	0.0	1.9	0.0	0.0	0.4	0.3	0.4	0.0	0.0	0.1	0.0	0.1	7
7C	0.5	0.0	0.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.3	0.0	0.2	0.0	0.0	0.2	0.1	7
11F	0.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.3	0.0	0.1	6
10F	0.5	0.0	0.0	0.0	0.0	1.9	0.0	0.0	0.0	0.0	0.0	0.3	0.0	0.0	0.0	0.1	0.1	0.1	5
12B	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.6	0.0	0.0	0.0	0.0	0.0	0.2	0.0	0.1	5
Others	1.0	2.7	1.9	6.0	1.2	0.0	8.1	0.0	0.0	1.8	0.4	1.6	0.0	0.9	0.3	0.8	0.6	0.9	58
Total	100	100	100	100	100	100	100	100	100	100	100	100	100	100	100	100	100	100	6,446

Not sero- typed	57.5	82.8	82.8	69.6	68.4	71.3	70.5	77.1	73.4	61.4	47.7	30.7	31.8	2.3	0.0	0.1	0.0	29.3	2,671

NT: nontypeable; : number of isolates tested.
Others includes the serotypes (number of isolates): 33B (4), 35A (4), 11B (3), 19C (3), 22A (3), 29 (3), 35C (3), 37 (3), 45 (3), 18B (2), 19B (2), 21 (2), 24A (2), 24B (2), 25F (2), 28F (2), 36 (2), 48 (2), 7B (2), 12 (1), 17A (1), 18 (1), 19 (1), 23 (1), 39 (1), 6 (1), 7A (1), 9 (1).