Cotrimoxazole Prophylaxis Specifically Selects for Cotrimoxazole Resistance in Streptococcus mutans and Streptococcus sobrinus with Varied Polymorphisms in the Target Genes folA and folP
Table 2
Comparison of the different antibiotic susceptibilities of the nonprophylaxis and prophylaxis groups*.
Antibiotic
STX prophylaxis use
OR
95% CI
No (%)
Yes (%)
Cotrimoxazole
S
71 (84.5)
29 (45.3)
6.59
2.89–15.37
R
13 (15.5)
35 (54.7)
Amoxicillin
S
61 (72.6)
41 (64.1)
1.49
0.02–118.67
R
1 (1.2)
1 (1.6)
I
22 (26.2)
22 (34.4)
Tetracycline
S
38 (45.2)
38 (59.4)
0.50
0.22–1.15
R
30 (35.7)
15 (23.4)
I
16 (19.0)
11 (17.2)
Erythromycin
S
74 (88.1)
49 (76.6)
3.02
0.63–19.37
R
3 (3.6)
6 (9.4)
I
7 (8.3)
9 (14.1)
Chloramphenicol
S
72 (85.7)
54 (84.4)
1.07
0.2–5.21
R
5(6)
4 (6.3)
I
7 (8.3)
6 (9.4)
Ceftriaxone
S
46 (54.8)
50 (78.1)
0.41
0.17–0.96
R
27 (32.1)
12 (18.8)
I
11 (13.1)
2 (3.1)
S: susceptible; R: resistant; *Intermediate resistance was not used in calculating OR.