In Vitro Antibacterial and Antibiotic Resistance Modifying Effect of Bioactive Plant Extracts on Methicillin-Resistant Staphylococcus epidermidis

Table 4

Interactions of essential oil from Salvia officinalis with oxacillin in effect on clinical strains of methicillin-resistant S. epidermidis.

S. epidermidis	FIC A	FIC B	FIC	Interpretation
Sep1	0.031	0.125	0.156	Synergistic
Sep2	0.062	0.250	0.312	Synergistic
Sep3	0.062	0.125	0.187	Synergistic
Sep4	0.062	0.250	0.312	Synergistic
Sep5	0.031	0.250	0.28	Synergistic
Sep6	0.031	0.125	0.156	Synergistic
Sep7	0.562	1.250	1.812	Indifferent

FIC A = MIC of substance A tested in combination/MIC of substance A tested alone, FIC B = MIC of substance B tested in combination/MIC of substance B tested alone. FICI = FIC A + FIC B. A—oxacillin, B—essential oil.