Comparative Analysis of Protein Glycosylation Pathways in Humans and the Fungal Pathogen Candida albicans

Figure 2

The O-linked mannosylation pathway. Human O-linked mannosyl glycans have been characterized mainly in alpha-dystroglycan where POMT1/2 add the first mannose residue that is further extended with other monosaccharides by the action of glycosyltransferases. The mannose residue can also be phosphorylated by the action of POMK, allowing further modification by disaccharide repeats of xylose and glucuronic acid synthesized by LARGE and LARGE2. Fukutin and FKRP genes are needed for correct glycosylation, but their roles remain to be clearly defined. In C. albicans, mannosylation involves the addition of the first mannose residue by the action of Pmt1-5, and that is further extended with four additional mannose residues by the action of Mnt 1 and Mnt2.