Review Article
Comparative Analysis of Protein Glycosylation Pathways in Humans and the Fungal Pathogen Candida albicans
Table 1
Human and C. albicans homolog proteins involved in the N-linked glycosylation pathway.
| | Protein function | Protein Human/Candida | Human ID* | Candida ID* | Id** | COV*** |
| | Glycosyltransferases | | | | | | | UDP-GlcNAc: Dol-P N-acetylglucosaminephosphotransferase | GT1/Alg7 | NP_001373.2 | XP_716028.1 | 37% | 87% | | UDP-GlcNAc: Dol-PP-GlcNAc N-acetylglucosaminyl transferase | Alg13 | NP_001093392.1 | XP_718987.1 | 30% | 60% | | UDP-GlcNAc: Dol-PP-GlcNAc N-acetylglucosaminyl transferase | Alg14 | NP_659425.1 | XP_717086.1 | 37% | 77% | | GPD-Man: Dol-PP-GlcNAc2 1,4-mannosyltransferase | Alg1 | NP_061982.3 | XP_711858.1 | 34% | 88% | | GPD-Man: Dol-PP-GlcNAc2Man 1,3-1,6-mannosyltransferase | Alg2 | NP_149078.1 | XP_710581.1 | 41% | 96% | | GPD-Man: Dol-PP-GlcNAc2Man3 and Man4 1,2-mannosyltransferase | Alg11 | NP_001004127.2 | XP_712508.1 | 36% | 67% | | Dol-P-Man: Dol-PP-GlcNAc2Man5 1,3-mannosyltransferase | Alg3 | NP_001006942.1 | XP_712080.1 | 30% | 81% | | Dol-P-Man: Dol-PP-GlcNAc2Man7 1,6-mannosyltransferase | Alg12 | NP_077010.1 | XP_716986.1 | 33% | 86% | | Dol-PP-Man: Dol-PP-GlcNAc2Man6 and Man8 1,3-mannosyltransferase | Alg9 | NP_001071158.1 | XP_713886.1 | 36% | 93% | | Dol-PP-Glc: Dol-PP-GlcNAc2Man9 1,3-glucosyltransferase | Alg6 | NP_037471.2 | XP_711029.1 | 37% | 87% | | Dol-PP-Glc: Dol-PP-GlcNAc2Man9Glc 1,3-glucosyltransferase | Alg8 | NP_001007028.1 | XP_721736.1 | 41% | 80% | | Dol-PP-Glc: Dol-PP-GlcNAc2Man9Glc2 1,2-glucosyltransferase | Alg10 | NP_116223.3 | XP_714677.1 | 32% | 96% | | Post flipping chaperone | Rft1 | NP_443091.1 | XP_717469.1 | 27% | 85% | | OST components | RBPH1/Ost1 | NP_002941.1 | XP_714694.1 | 27% | 85% | | DAD1/Ost2 | NP_001335.1 | XP_714366.1 | 40% | 81% | | N33/Ost3 | NP_006756.2 | XP_721902.1 | 23% | 77% | | Ost4 | NP_001128165.1 | EEQ47486.1 | 39% | 51% | | IAP/Ost6 | NP_115497.4 | XP_716090.1 | 22% | 84% | | RIBIIR/SwpI | NP_002942.2 | XP_721287.1 | 26% | 58% | | OST48 /Wbp1 | NP_005207.2 | XP_713903.1 | 24% | 91% | | STT3A/Stt3 | NP_001265432.1 | XP_722527.1 | 56% | 94% | | STT3B | NP_849193.1 | | 57% | | | Folding Sensor | UGGT1/Kre5 | NP_064505.1 | XP_719987.1 | 60% | 57% | | Glycosidases | | | | | | | Glucosidase I | MOGS/Cwh41 | NP_001139630.1 | ABB97046.1 | 29% | 91% | | Glucosidase II | GANAB/Rot2 | NP_938148.1 | XP_716812.1 | 38% | 98% | | GLU2B/Gtb1 | NP_002734.2 | XP_717976.1 | 39% | 57% | | ER 1,2-mannosidase I | MAN1B1/MnsI | NP_057303.2 | XP_713641.1 | 45% | 77% |
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Accession number at NCBI database.
Identity and coverage from BLAST alignment between human and C. albicans homolog sequences, respectively.
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