Genomic Variability among Field Isolates and Laboratory-Adapted Strains of Leptospira borgpetersenii Serovar Hardjo

Figure 2

Reference genes with at least one variant of moderate to high predicted impact in our sequenced specimens of the corresponding subtypes. Core genes are indicated by a (c) and genes with similarity to previously reported virulence factors are indicated with a (v). Variants that putatively generated a pseudogene in the genome of the corresponding specimen are italic. Variants are labelled by using the protein (p.) part of the HGVS nomenclature (http://www.hgvs.org/mutnomen/). In this notation, “del” means deletion, “ins” means insertion, “dup” means duplication, “fs” means frameshift, and “” indicates a stop codon gained. † indicates that the corresponding gene has more than one mutation; see Table for the full list of mutations.