Association between Cystatin C and MRI Measures of Left Ventricular Structure and Function: Multi-Ethnic Study of Atherosclerosis

Table 2

The association of cystatin C with LV parameters in nested models showing P trend with increasing cystatin C quartiles.

Outcomes variables	Quartile 1	Quartile 2	Quartile 3	Quartile 4	P trend
Model 1 (𝑛=4,970)
LVEDV, ML	125.7±0.8	128.7±0.9	127.0±0.9	123.9±1.0	0.12
LVESV, ML	39.5±0.4	41±0.5	40.2±0.5	39.2±0.5	0.55
LVM, Gm	138.0±1.0	144.8±1.1	148.2±1.2	151.9±1.2	0.0001
LVM/LVEDV, Gm/ML	1.11±0.01	1.14±0.01	1.19±0.01	1.25±0.01	0.0001
EF, %	69.2±0.2	68.8±0.2	69.0±0.2	69.2±0.2	0.90
Model 2 (𝑛=4,970)
LVEDV, ML	128.1±0.7	127.5±0.7	125.5±0.7	124.3±0.8	0.0002
LVESV, ML	40.1±0.4	40.1±0.4	39.2±0.4	39.2±0.5	0.07
LVM, Gm	145.7±0.8	145.1±0.8	144.9±0.8	148.0±0.9	0.12
LVM/LVEDV, Gm/ML	1.15±0.01	1.15±0.01	1.17±0.01	1.21±0.01	0.0001
EF, %	69.4±0.2	69.3±0.2	69.4±0.2	69.2±0.2	0.71
Model 3 (𝑛=4,946)
LVEDV, ML	128.2±0.7	127.6±0.7	125.5±0.7	124.0±0.8	0.0001
LVESV, ML	40.1±0.4	40.1±0.4	39.1±0.4	39.0±0.5	0.04
LVM, Gm	146.1±0.8	145.7±0.7	145.3±0.8	147.3±0.8	0.45
LVM/LVEDV, Gm/ML	1.15±0.01	1.16±0.01	1.17±0.01	1.21±0.01	0.0001
EF, %	69.5±0.2	69.3±0.2	69.5±0.2	69.3±0.2	0.75

Cystatin C quartiles 1: ≤0.76, quartile 2: >0.76 & ≤0.86, quartile 3: >0.86 & ≤0.98, quartile 4: >0.98 in mg/dL; LV parameters in adjusted least square mean ± standard error. LVEDV: LV end diastolic volume; LVESV: LV end systolic volume; LVM: LV mass; LVM/LVEDV: LV concentricity; EF: ejection fraction (fraction).
Model 1 univariate analysis; Model 2 adjusted for age, race/ethnicity, gender, height, and weight; Model 3 adjusted for Model 2 plus diabetes, use of antidiabetic medications, hypertension history, systolic blood pressure, total cholesterol, antilipid medications, and smoking.