Therapeutic Options for the Management of the Cardiorenal Syndrome

Table 2

Pharmacokinetics of loop diuretics according to the renal function in heart failure patients. IV: intravenous; CrCl: Creatinine Clearance.

	Moderate renal insufficiency	Severe renal insufficiency			Heart failure
	Maximal intravenous dose (mg)			IV Loading dose (mg)	Infusion rate (mg/hr)
Diuretic					CrCl <25 ml/min	CrCl; 25–75 ml/min	CrCl >75 ml/min
Furosemide	80–160	160–200	40–80	40	20 then 40	10 then 20	10
Bumetanide	4–8	8–10	1–2	1	1 then 2	0.5 then 1	0.5
Torsemide	20–50	50–100	10–20	20	10 then 20	5 then 10	5