Heart-Kidney Biomarkers in Patients Undergoing Cardiac Stress Testing

Table 1

Baseline demographic, laboratory, and cardiovascular parameters according to the amount of myocardial ischemia (number of inducible myocardial perfusion defects).

Baseline variable	High inducible ischemia (𝑛=18)	Low inducible ischemia (𝑛=16)	P value
Demographic
Age (years)	70.4±6.7	67.6±7.5	.25
Sex (% male)	77.8	75.0	.85
Weight (kg)	80.5±12.1	78.1±8.0	.66
Past history (%)
Hypertension	38.9	43.8	.77
Current smoking	0.0	18.8	.09
Dyslipidemia	66.7	56.3	.53
Diabetes mellitus	22.2	12.5	.46
Myocardial infarction	77.8	43.8	.08
Coronary angioplasty	88.9	50.0	.02
Coronary bypass graft	5.6	12.5	.48
Medications (%)
Nitrates	16.7	18.8	.87
Calcium antagonists	33.3	12.5	.23
Beta blockers	27.8	31.3	.82
Laboratory
Creatinine (𝜇mol/L)	86.0±27.2	75.6±16.6	.19
Albumin (g/L)	45.3±2.3	44.6±2.4	.39
Hemoglobin (g/L)	140.7±13.4	147.0±13.5	.18
Glucose (mmol/L)	6.4±1.0	5.9±0.7	.15
BNP (pg/mL)	80.3±60.6	52.9±43.9	.15
cTnI (𝜇g/L)	0.010±0.009	0.008±0.007	.45
NT-proBNP (pg/mL)	580.4±712.9	289.9±215.8	.13
AOPP (𝜇mol/L)	121.2±116.3	77.0±28.5	.15
NGAL (ng/mL)^†	67.5 (60.0–115.5)	67.0 (60.0–90.8)	.60
Cardiovascular parameters (at rest)
End diastolic volume (mL)	101.3±29.7	105.2±27.9	.70
End systolic volume (mL)	46.5±24.5	43.8±19.1	.73
Ejection fraction (%)	56.7±10.6	61.1±12.1	.27

^†Data presented as median (IQR).
BNP: B-type natriuretic peptide, cTnI: cardiac troponin I, NT-proBNP: N-terminal-pro-B-type natriuretic peptide, AOPP: advanced oxidation protein products, NGAL: neutrophil gelatinase-associated lipocalin.