Bioincompatible Impact of Different Peritoneal Dialysis Fluid Components and Therapeutic Interventions as Tested in a Rat Peritoneal Dialysis Model

Table 1

The degree of contribution by extrinsic (catheter, uremia) and intrinsic (fluid) factors on the peritoneum in rats.

Peritoneal changes	Extrinsic factors		Intrinsic factors
	Catheter	Uraemia	(Lactate) Buffer	Buffer + Glucose	Buffer + Glucose + GDP
Ultrafiltration failure	−	±	±	+	++
Angiogenesis	±	±	±	+	++
Fibrosis	−	−	−	+	++
Mesothelial regeneration	−	−	+	++	++
Effluent cell number	−	−	−	+	+
Omental mast cells	−	±	+	+	++
Omental milky spots	−	−	+	+	++

GDP = glucose degradation products.
Peritoneal changes are scored from no (−), weak (±), and moderate (+) to very strong alterations (++) compared to control rats.