Review Article

Low Birth Weight due to Intrauterine Growth Restriction and/or Preterm Birth: Effects on Nephron Number and Long-Term Renal Health

Table 1

Summary of the studies that have examined blood pressure and renal function in children and adults that were born preterm.

Blood pressure
AuthorsNumber and sex of participantsWeeks gestational age at birthAge of subjects at examination (years)Major findings in participants born preterm

Cooper et al. [83]7847
Males and females
<3744–45Higher DBP
Inverse association between GA and systolic BP

Bonamy et al. [86] 60
Males and females
≤307–12 Higher SBP and heart rate
Lower dermal capillary density

Dalziel et al. [92] 458
Males and females
32–3530Higher SBP
Insulin resistance

Keijzer-Veen et al. [79]82
Males and females
<3220Higher SBP

Lawlor et al. [82] 386,485
Males
35–4418Both birthweight and GA inversely correlated with systolic blood pressure

Bonamy et al. [87] 66
Females
23–3416.5Higher brachial and aortic blood pressures (DBP and SBP)
Narrower abdominal aortas
Increased vascular resistance

Hack et al. [81] 195
Males and females
3020Higher systolic blood pressure

Johansson et al. [80] 404,306
Males
24–4318Higher SBP

Keijzer-Veen et al. [78]596
Males and females
<3219Increased prevalence of high blood pressure

Doyle et al. [77]270
Males and females
24–36
18.6
Higher SBP and DBP

Stevenson et al. [85] 128
Males and females
26–3715Higher SBP

Kistner et al. [76] 50
Females
28–3223–26Higher SBP and DBP

Siewert-Delle and Ljungman [84]430
Males
30–37 49SBP inversely related to gestational age

Renal function
AuthorsNumber and sex of participantsWeeks of gestational age at birth (range)Age of subjects at examination (years)Major findings in participants born preterm

Kwinta et al. [89]116
Males and females
26–296–7Increased serum cystatin-C levels
Decreased kidney volume
No difference in microalbuminuria

Zaffanello et al. [90] 69
Males and females
26–315–6Urine α1-microglobulin levels significantly increased in
ELBW versus VLBW
No difference in GFR or microalbuminuria in ELBW versus VLBW

Bacchetta et al. [91] 50
Males and females
<377.6Lower GFR in IUGR and EUGR
No difference in microalbuminuria

Rakow et al. [93] 105
Males and females
<32 9–12 No difference in GFR or microalbuminuria
Smaller kidney volume

Keijzer-Veen et al. [79]82
Males and females
<3220Greater filtration fraction in preterm AGA
Increased microalbuminuria in preterm SGA

Iacobelli et al. [94]48
Males and females
<376.3–8.2 Increased microalbuminuria
No difference in GFR

Keijzer-Veen et al. [88] 422
Males and females
<3219Lower GFR in SGA
Increased microalbuminuria in SGA

Rodríguez-Soriano et al. [95] 40
Males and females
23–356.1–12.4Lower GFR
No difference in kidney size or blood pressure

Kistner et al. [76] 50
Females
28–3223–26No difference in GFR or effective renal plasma flow
No difference in microalbuminuria

Vanpee et al. [96] 34
Males and females
25–308No difference in GFR or effective renal plasma flow
No difference in microalbuminuria

GA: gestational age; DBP: diastolic blood pressure; SBP: systolic blood pressure; GFR: glomerular filtration rate; AGA: appropriate weight for gestational age; SGA: small for gestational age; ELBW: extremely low birth weight (<1kg); VLBW: very low birth weight (1–1.5 kg); IUGR: intrauterine growth restriction; EUGR: extrauterine growth restriction.