Calcific Uremic Arteriolopathy on Multimodal Combination Therapy: Still Unmet Goal

Table 1

Patients’ characteristics and clinical course in subjects with end-stage renal failure presenting with calciphylaxis.

Subject	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5	Patient 6
Age (years)	48	53	63	72	74	86
Gender	Female	Female	Female	Female	Male	Male
Cause of ESRF	Diabetes	Chronic GN	Diabetes	Diabetes	Diabetes	Obstructive uropathy
Duration RRT (months)	12	36	24	21	15	12
Site of lesion	Extensive*	Distal	Distal	Extensive	Distal	Distal
Microorganism	Pseudomonas	MRSA	Klebsiella	Pseudomonas	Pseudomonas	MRSA+pseudomonas
Mode of therapy**	Cinacalcet STS	PTHX HBO	PTHX HBO STS prednisolone	Cinacalcet prednisolone	STS HBO amputation	Cinacalcet HBO
Outcome	Dead	Dead	Dead	Dead	Dead	Alive
Cause of death	Sepsis	Myocardial infarction	Sepsis	Myocardial infarction	Sepsis	Not applicable
Comorbidities	DM ESRF IHD HTN Asthma	Epilepsy ESRF gout	DM ESRF gout	IHD DM ESRF MGUS	DM ESRF HTN arthritis	ESRF
Skin lesion outcome	Failed	Healed	Failed	Healed	Failed	Healed
Survival (months)	1	32	5	4	4	Alive

ESRF: end-stage renal failure, GN: glomerulonephritis, RRT: renal replacement therapy, *: extensive skin lesions involving the lower limbs, genitalia, abdominal wall, and breast, MRSA: methicillin resistant Staph aureus, **: mode of therapy apart from general wound care and antibiotics, STS: sodium thiosulphate, PTHX: parathyroidectomy, HBO: hyperbaric oxygen, IHD: ischemic heart disease, HTN: hypertension, MGUS: monoclonal gammopathy of unknown significance.