Review Article

Mechanisms of Glomerular Albumin Filtration and Tubular Reabsorption

Table 1

Comparison of the glomerular albumin-sieving coefficient (SC) values.

Authors, yearMethodSCSpecies/animal model

Tojo and Endou [12], 1992Fractional micropuncture0.00062rat

Bertolatus and Hunsicker [62], 1985131I-labeled BSA measuring urinary excretion and total kidney uptake minus interstitial nonfiltration uptake0.0006rat
0.021hexadimethrine nephrotic rat
0.025adriamycin nephrotic rat
131I-labeled neutral BSA0.026rat

Lund et al. [18], 2003125I-native human serum albumin measuring both kidney uptake and urinary excretion0.00066rat
125I-neutral human serum albumin0.0065rat

Norden et al. [13], 2001urinary albumin excretion of congenital Fanconi syndrome patients0.00008human

Tencer et al. [63], 1998 Blockade of proximal tubular reabsorption by L-lysine0.00033rat
0.0591puromycin aminonucleoside nephrotic rat

Ohlson et al. [64], 2000Inhibition of tubular function by cooling (8°C)0.0019rat

Christensen et al. [23], 2007urinary albumin excretion of megalin-knockout mice0.00016megalin-knockout mice

Eppel et al. [14], 1999tritium-labeled albumin0.074rat

Russo et al. [15], 2007Alexa-labeled albumin, confocal microscopy0.0341rat

Tanner [16]Alexa-labeled rat serum albumin, two-photon microscope with internal photodetectors0.002Munich-Wistar rat