Review Article
Mechanisms of Glomerular Albumin Filtration and Tubular Reabsorption
Table 1
Comparison of the glomerular albumin-sieving coefficient (SC) values.
| Authors, year | Method | SC | Species/animal model |
| Tojo and Endou [12], 1992 | Fractional micropuncture | 0.00062 | rat |
|
Bertolatus and Hunsicker [62], 1985 | 131I-labeled BSA measuring urinary excretion and total kidney uptake minus interstitial nonfiltration uptake | 0.0006 | rat | 0.021 | hexadimethrine nephrotic rat | 0.025 | adriamycin nephrotic rat | 131I-labeled neutral BSA | 0.026 | rat |
|
Lund et al. [18], 2003 | 125I-native human serum albumin measuring both kidney uptake and urinary excretion | 0.00066 | rat | 125I-neutral human serum albumin | 0.0065 | rat |
| Norden et al. [13], 2001 | urinary albumin excretion of congenital Fanconi syndrome patients | 0.00008 | human |
|
Tencer et al. [63], 1998 |
Blockade of proximal tubular reabsorption by L-lysine | 0.00033 | rat | 0.0591 | puromycin aminonucleoside nephrotic rat |
| Ohlson et al. [64], 2000 | Inhibition of tubular function by cooling (8°C) | 0.0019 | rat |
|
Christensen et al. [23], 2007 | urinary albumin excretion of megalin-knockout mice | 0.00016 | megalin-knockout mice |
| Eppel et al. [14], 1999 | tritium-labeled albumin | 0.074 | rat |
| Russo et al. [15], 2007 | Alexa-labeled albumin, confocal microscopy | 0.0341 | rat |
| Tanner [16] | Alexa-labeled rat serum albumin, two-photon microscope with internal photodetectors | 0.002 | Munich-Wistar rat |
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