Clinical Study

Impairment and Differential Expression of PR3 and MPO on Peripheral Myelomonocytic Cells with Endothelial Properties in Granulomatosis with Polyangiitis

Table 1

Patients’ characteristics. A BVAS of 0 with a prednisolone dose below or equal to 7.5 mg/d defined remission while an active disease was defined by a BVAS ≥1. Patients with a BVAS of ≥8 were defined as highly active, a BVAS of <8 defined low activity. Diagnosis of GPA was according to the ACR criteria. Column 4 from the left displays the criteria that were fullfilled by an individual patient.

No.AgeDiagnosisACR Criteria+Previous drugsPR3 (U/mL)MPO (U/mL)Creatinine (mg/dL)CRP (mg/dL)Maintenance therapyBVASVDIGenderDisease durationRenal histologyANCA

175GPARenal, lungsCyc24neg3.5418.1Cyc, Prednisone1210m2 monthRenal involvement but no renal biopsy performed 1 : 80
266GPAENT, lungsCyc, MTX11neg0.9310.5Cyc, Prednisone75m10 yearsNo biopsy 1 : 20
361GPAENT, lungs, renalCyc, MTXnegneg0.993.1Prednisone106m15 yearsFocal segmental necrotizing glomerulonephritis 1 : 20
475GPALungs, renalnone301neg3.31112Prednisone, PS193m1 dayFocal segmental necrotizing glomerulonephritis 1 : 640
551GPAENT, lungsCyc, MMFnegneg0.93Prednisone55f4 yearsRenal involvement but no renal biopsy performed 1 : 20
667GPAENT, lungs, renalCyc, MTX9neg1.25.7Lefl, Prednisone99m22 yearsRenal involvement but no renal biopsy performed 1 : 40
756GPAENT, lungsPrednisone, AZA25neg0.82Prednisone, AZA83f2 monthNo biopsy 1 : 160
858GPAENT, lungsMTXnegneg0.572Prednisone, AZA512f8 yearsNo biopsy neg
962GPAENT, lungs, renalCycnegneg1.022Prednisone, AZA45m8 yearsFocal segmental necrotizing glomerulonephritisneg
1042GPAENT, ENT granulomasCyc, MTX11neg0.843.5Cyc, prednisone77f2 yearsNo biopsy 1 : 20
1132GPAENT, ENT granulomasCyc, AZA, Infli5.3neg0.8318.4Prednisone, MMF78f5 yearsNo biopsy 1 : 20
1257GPALungs, renalCyc, MTXnegneg1.723.3Prednisone, MMF107m12 yearsFocal segmental necrotizing glomerulonephritis1 : 20
1330GPALungs, renalCyc, AZA, PP6.4neg0.92.2AZA61m4 yearsFocal segmental necrotizing extracapillary proliferating glomerulonephritis with intermediate interstitial nephritis 1 : 20
1470GPALungs, renalCyc, AZAnegneg4.142Prednisone, AZA108f8 yearsFocal segmental necrotizing, extracapillary proliferating glomerulonephritis neg
1572GPAENT, lungsCyc88neg2.354.7Prednisone, AZA216m10 yearsRenal involvement but no renal biopsy performed 1 : 320
1625GPAENT, renalCyc, PS25neg1.144.5Cyc, Prednisone133m5 yearsFocal segmental necrotizing, intra- and extracapillary proliferating glomerulonephritis1 : 80
1769GPAENT, lungsCyc, AZA, MTX6.8neg1.172Prednisone27m9 yearsNo biopsy 1 : 20
1856GPAENT, lungs, renalCyc, AZAnegneg0.672AZA73m6 yearsFocal segmental necrotizing glomerulonephritis 1 : 80
1953GPALungs, renalCyc,AZA5neg2.112.1Prednisone, AZA46m7 yearsFocal segmental necrotizing extracapillary proliferating glomerulonephritis with mild interstitial nephritis neg
2084GPAENT, lungs, renalCyc, Prednisone12neg1.6468Prednisone75m10 yearsRenal involvement but no renal biopsy performed1 : 40
2183GPALungs, renalMMF, Prednisone7neg1.057MMF, Prednisone28m2 yearsRenal involvement but no renal biopsy performed 1 : 20
2280GPARenal, renal histologyCyc, Prednisone5.5neg2.09.9None32f10 yearsFocal segmental necrotizing. extracapillary proliferating glomerulonephritis 1 : 80
2369GPAENT, lungs, renalCyc, AZA260neg1.086.4AZA44f6 yearsFocal segmental glomerulosclerosis with chronic interstitial nephritis 1 : 320
2465GPAENT, lungsCyc, Prednisone1.1neg0.837.1Prednisone, MTX35f5 yearsNo biopsy neg
2564GPALungs, renalCyc, PP, AZA16neg1.945Prednisone, MMF99f4 monthFocal segmental necrotizing glomerulonephritis1 : 40
2671MPALungs, polyneuropathy, arthralgiaCycneg871.0415.5Prednisone155m6 monthNo biopsy 1 : 80
2786MPALungs, renal, polyneuropathyCyc, PPneg1340,7940Cyc72m7 yearsFocal segmental necrotizing glomerulonephritis 1 : 40
2876MPARenalCycneg881.582Prednisone45f11 yearsNo biopsy 1 : 80
29MPALungs, poyneuropathyCyc, PSneg670.889.6Prednisone, Cyc153m3 monthNo biopsy 1 : 40
3076MPARenalMMFneg751.934.3Prednisone, MMF72m2 yearsNo biopsy 1 : 20
3157MPAArthralgiaPrednisoneneg710.842Prednisone10f1 yearNo biopsy 1 : 20
3261MPAESRD, lungsAZA, MMFneg446.7511.4Prednisone96f6 yearsNo biopsy 1 : 160
3373MPALungs, renal, neurologicCyc, PPneg1950.8732.5Prednisone, Cyc1310f1 yearNo biopsy 1 : 320
3472MPAArthralgiaPrednisoneneg1101.022none22f4 yearsNo biopsy 1 : 160
3586MPAArthralgiaCycneg2005.137.2Prednisone, Cyc144f8 yearsNo biopsy1 : 160