Is the Antiproteinuric Effect of Cyclosporine A Independent of Its Immunosuppressive Function in T Cells?
Figure 1
The calcineurin-activation-induced podocyte injury. Upon activation by increased intracellular Ca2+, calcineurin dephosphorylates the NFAT proteins and synaptopodin [5, 6]. NFAT activation induces podocyte apoptosis [11] and glomerulosclerosis [6]. TRPC6-mediated Ca2+ influx stimulates NFAT-dependent TRPC6 expression [7]. Rcan1, Wnt6, and Fzd9 were shown to be upregulated in glomeruli isolated from transgenic mice, making them potentially direct targets of NFAT [6].
