Congenital Anomalies of the Kidney and Urinary Tract: A Genetic Disorder?

Figure 1

Schematic representation of the proposed impact of intrauterine environment, gene mutations, epigenotype, and urinary flow obstruction on the pathogenesis of CAKUT. These factors cause aberrant interactions among the mesenchyme, ureteric bud (UB), or bladder anlagen to result in CAKUT [102]. Please see text for details.