Effect of Intensive Blood Pressure Control on Cardiovascular Remodeling in Hypertensive Patients with Nephrosclerosis
Table 4
Mean (SE) rate of change of blood pressure measurements after 9 months of follow-up by randomized treatment assignment (mmHg/year).
Treatment assignment
Both BP groups
Low BP goal
Usual BP goal
P value for low versus usual BP
Pulse pressure
ACE
0.85 (0.15)
0.57 (0.22)
1.13 (0.21)
BB
0.68 (0.17)
0.38 (0.25)
0.99 (0.23)
CCB
0.71 (0.27)
0.24 (0.39)
1.18 (0.38)
All drug groups
0.75 (0.11)
0.42 (0.15)
1.08 (0.15)
0.002
Systolic BP
ACE
−0.02 (0.22)
−0.38 (0.32)
0.34 (0.31)
BB
−0.25 (0.21)
−0.68 (0.31)
0.18 (0.28)
CCB
−0.64 (0.32)
−1.28 (0.47)
−0.01 (0.45)
All drug groups
−0.24 (0.14)
−0.68 (0.20)
0.21 (0.19)
0.001
Diastolic BP
ACE
−0.84 (0.14)
−0.90 (0.21)
−0.78 (0.18)
BB
−0.88 (0.12)
−1.01 (0.17)
−0.76 (0.17)
CCB
−1.33 (0.21)
−1.54 (0.32)
−1.12 (0.26)
All drug groups
−0.96 (0.08)
−1.07 (0.13)
−0.84 (0.11)
0.16
Analysis based on pulse pressures at non-GFR protocol visits from 9 months after randomization through the end of follow-up. The analysis was restricted to 1043 patients with at least 1 blood pressure measurement after 9 months and was performed without covariate adjustment.
