Developmental Origins of Chronic Renal Disease: An Integrative Hypothesis

Figure 2

Proposed pathophysiological mechanism of renal injury (glomerular endothelium barrier disruption, podocyte dysfunction, interstitial fibrosis, tubular ischemia). FSA: filtration surface area; GFR: glomerular filtration rate; SNGFR: single nephron glomerular filtration rate; RAS: rennin angiotensin system; VEGF: vascular endothelial growth factor system; ∑: sympathetic nervous system.