Effect of the Direct Renin Inhibitor Aliskiren on Urinary Albumin Excretion in Spontaneous Type 2 Diabetic KK-𝐴^𝑦 Mouse

Table 1

Biochemical profiles of KK mice and KK-𝐴^𝑦 mice.

Mice; 𝑛	Untreated KK; 7	Untreated KK-𝐴^𝑦; 10	Treated KK-𝐴^𝑦; 11
8 weeks of age
Body weight (g)	26.0 ± 0.3*	31.1 ± 0.8	31.3 ± 1.6
Systolic blood pressure (mmHg)	103 ± 4	104 ± 2	105 ± 2
Urinary albumin-creatinine ratio (mg/g⋅Cr)	47 ± 22*	158 ± 54	150 ± 78
Fasting blood glucose (mg/dL)	83 ± 5*	110 ± 6	110 ± 7
HbA1c (%)	4.0 ± 0.2**	4.3 ± 0.3	4.2 ± 0.1
12 weeks of age
Body weight (g)	32.8 ± 0.5*	38.9 ± 0.8	38.8 ± 1.9
Systolic blood pressure (mmHg)	116 ± 5	116 ± 28	96 ± 2*
Urinary albumin-creatinine ratio (mg/g⋅Cr)	24 ± 10*	552 ± 268	112 ± 99*
Fasting blood glucose (mg/dL)	106 ± 5	108 ± 7	105 ± 10
HbA1c (%)	4.3 ± 0.2*	6.9 ± 0.4	6.7 ± 0.2

Data are expressed as means ± SD.
^∗𝑃<0.01 (versus untreated KK-𝐴^𝑦 mice group), **𝑃<0.05 (versus untreated KK-𝐴^𝑦 mice group).