Comparison of CKD-EPI Cystatin C and Creatinine Glomerular Filtration Rate Estimation Equations in Asian Indians

Table 2

(a) Distribution of mean estimated GFR by BMI categories. (b) Distribution of mean estimated GFR by disease subgroups.

(a)

Equation	Mean estimated GFR* (mL/min/1.73 m^2)
	All patients	Body mass index (kg/m^2)				𝑃 for trend
		<20	20–25	25–30	>30
Creatinine 2009—age, sex, and race	88±17	87±18	88±17	88±17	89±19	0.2
Cystatin C 2012—age and sex	83±21	83±23	85±21	83±20	78±21	<0.001
Creatinine-cystatin C 2012 (age, sex, and race)	86±19	85±20	87±19	86±18	84±20	0.02
Average of creatinine 2009 and cystatin C 2012	85±17	85±19	86±17	85±17	84±23	0.03
Spline Log cystatin C	88±22	89±2	90±22	88±22	83±23	<0.001
Spline Log cystatin C—age, sex, and race	82±21	82±23	84±20	83±20	77±21	<0.001
Spline Log cystatin C—age, sex, and diabetes	85±20	84±22	86±20	85±20	80±21	<0.001
Spline Log cystatin C—age, sex, and weight	81±21	78±22	82±20	82±20	79±22	0.8

∗Estimated GFR reported as mean ± SD.

(b)

Equation	Mean estimated GFR* (mL/min/1.73 m^2)
	Nondiabetic	Diabetic	𝑃 value	Nonhypertensive	Hypertensive	𝑃 value
Creatinine 2009 (age, sex, and race)	90±16	85±20	<0.001	92±15	84±18	<0.001
Cystatin C 2012 (age and sex)	84±19	80±23	<0.001	88±19	78±21	<0.001
Creatinine-cystatin C 2012 (age, sex, and race)	87±17	83±22	<0.001	91±16	82±19	<0.001
Average of creatinine 2009 and cystatin C 2012	87±16	82±20	<0.001	90±15	81±18	<0.001
Spline Log cystatin C	89±21	86±25	0.009	93±21	84±23	<0.001
Spline Log cystatin C—age, sex, and race	83±19	80±23	<0.001	88±19	78±21	<0.001
Spline Log cystatin C—age, sex, and diabetes	84±19	86±24	0.01	89±18	81±21	<0.001
Spline Log cystatin C—age, sex, and weight	82±19	79±23	<0.001	87±19	77±21	<0.001

∗Estimated GFR reported as mean ± SD.