Analysis of T Cell Subsets in Adult Primary/Idiopathic Minimal Change Disease: A Pilot Study

Figure 8

Selected correlation plots between lymphocyte and T cell subsets and clinical outcomes at disease onset in primary MCD. This figure is supplementary to Table 3, where the complete list of statistically significant correlations between outcomes and other disease subsets is found. Only the comparisons that were (1) statistically significant, (2) related to outcomes at disease onset (t0), (3) related to our original hypothesis that the immune balance in MCD is tilted towards a dominance of Th17 and cytotoxic cells over the Foxp3⁺ Treg subset, and (4) discussed in the text are plotted here for visual reference. Correlations plotted: number of circulating CD8⁺ T cells with serum creatinine (a); number of circulating CD8⁺ T cells with MDRD GFR (b); percentage of kidney tissue infiltrating CD4⁺ T cells with proteinuria (c); percentage of circulating naïve CD8⁺ T cells with proteinuria (d); and ratio of tissue cytotoxic over Foxp3⁺ Treg cells with MDRD GFR (e).

(a)

(b)

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