Review Article
Scientific Rationale for the Use of Alpha-Adrenergic Agonists and Glucocorticoids in the Therapy of Pediatric Stridor
Table 2
Effects of αAR-agonists and glucocorticoids in upper airway breathing mechanics.
| Treatment modality | Physiological effects |
| αAR-agonists | (i) Increased nasal inspiratory flow (PNIF) | (ii) Decreased oropharyngeal resistance and collapsibility | (iii) Decreased total respiratory resistance () | (iv) Decreased inspiratory and expiratory resistance (R AW0.5I and R AW0.5E) | (v) Decreased work of breathing (WOB) | (vi) Paradoxical nasal obstruction (vasomotor rebound) | (vii) Rebound increase in total respiratory resistance () |
| Glucocorticoids | (i) Increased nasal inspiratory flow (PNIF) | (ii) Decreased nasal airway resistance (NAR) | (iii) Increased nasal volume by acoustic rhinometry (AR) | (iv) αAR-induced vasomotor rebound prevention (changes in PNIF, AR and NAR) |
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