Review Article
Sinonasal Malignancies and Charged Particle Radiation Treatment: A Systematic Literature Review
Table 1
Patient, tumor, and treatment characteristics of reports regarding patients with sinonasal malignancies treated with protons or ions.
| | Reference | Years | Patients, Gender | Median age in years (range) | Pathology | Stage | Surgery | Chemotherapy | Radiation therapy | F/U months (range) |
| | Castro et al., 1994 [40] | 1977–1992 | 22
M/F na | na | na | All with skull base invasion | na | na | Full Particle: 75%
Mixed Ph/Pr: 25% | 51 (4–191)1 |
| | Tokuuye et al., 2004 [42] | 1983–2000 | 11
6 M/5 F | 67 (40–78) | SCC: 5
MM: 2
Others: 4 | IV: 4
II: 1
III: 1
Rec/na: 6 | 3 nos | 3 nos | Full Hadron: 4/11
Mixed Ph/Pr: 7/11 | 23 (6–58) |
| | Mizoe et al., 2004 [31] | 1994–1997 | 10
M/F na | na | na | All locally advanced | All bx | na | Full Particle | 90 (77–108)1 |
| | Resto et al., 2008 [43] | 1991–2002 | 102
53 M/49 F | 50 (15–82) | SCC: 33
CNE: 30
ACC: 20
Others: 19 | All locally advanced | CR: 20
PR: 50
Bx: 32 | 30: Ind.
EPD/CDDP
4: Other | Mixed Ph/Pr: 100% | 43.2 (1.32–156.6) |
| | Zenda et al., 2011 [44] | 1999–2006 | 39
22 M/17 F | 57 (22–84) | SCC: 11
ONB: 9
MM: 6
Others: 13 | All T4N0M0 | All Bx | Ind.: 10
Con.: 1 | Full Particle | 45.4 (1.3–90.9) |
| | Malyapa et al., 2010 [39] | 2007–2009 | 38
M/F na | na | na | All with skull base extension | R0: 18
R+: 17
Bx: 3 | na | Full Particle | 13.1 (1–29) |
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1Data refers to a wider group of head and neck patients included in the same study. SCC: squamous cell carcinoma, MM: malignant melanoma, ACC: adenoid cystic carcinoma, CNE: carcinoma with neuroendocrine features, ONB: olfactory neuroblastoma, na: not available, Rec: recurrence, nos: not otherwise specified, Ph: photon, Pr: particles, CR: complete resection, PR: partial resection, Bx: biopsy, Ind.: induction, EPD: etoposide, CDDP: cisplatin, Con.: concurrent, R0: negative resection margins, R+: positive resection margin, F/U: followup.
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