Review Article

Interaction between Chronic Inflammation and Oral HPV Infection in the Etiology of Head and Neck Cancers

Table 3

Association between periodontitis and head and neck cancer stratified by tumor site ( ).

Alveolar bone loss (per millimeter) (cases/controls)Crude OR [95% CI]*Adjusted  OR [95% CI]

All HNSCC patients266/2073.85 [2.96–5.01]4.36 [3.16–6.01]
 Oral cavity SCC patients100/2073.26 [2.44–4.36]4.52 [3.03–6.75]
 Oropharyngeal SCC patients115/2073.06 [2.29–4.07]3.64 [2.54–5.22]
 Laryngeal SCC patients51/2073.75 [2.60–5.41]2.72 [1.78–4.16]

*Odds ratios and their 95% confidence intervals.
Adjusted odds ratios were derived from multiple logistic regression analysis including age at diagnosis, gender, race/ethnicity, marital status, smoking status, alcohol use, ABL, and missing teeth.