Prevalence of K-RAS Codons 12 and 13 Mutations in Locally Advanced Head and Neck Squamous Cell Carcinoma and Impact on Clinical Outcomes

Table 1

Patient characteristics and treatment intentions.

Characteristic	K-RAS codon 12 (no mutation)	K-RAS codon 12 (mutation)	K-RAS codon 13	All
Sex—M/F	144/44	6/1	—	150/45
Age—yr	56	62	—	56
Stage
II	2	0	0	2
III	31	0	0	31
IV	148	6	0	154
Relapse	7	1	0	8
Site of primary tumor
Mouth	21	0	0	21
Oropharynx	119	4	0	123
Larynx	26	3	0	29
Hypopharynx	11	0	0	11
Other	11	0	0	11
Tumor stage
T1	21	1	0	22
T2	39	1	0	40
T3	60	1	0	61
T4	61	3	0	64
Nodal stage
N0	21	0	0	21
N1	31	0	0	31
N2	103	5	0	108
N3	25	1	0	26
Radiotherapy
Conventional	170	6	0	176
Adjuvant	18	0	0	18
Chemotherapy
Cisplatin	61	1	0	62
Carboplatin	126	6	0	132