|
| Author | Year | Patients | Surgery | Treatment dosage | Treatment duration | Treatment start to leak cessation | Additional measures | Comments |
|
| Somatostatin |
|
| Coşkun and Yildirim [19] | 2010 | 1 | Thyroidectomy + L MRND | 3 mg iv Qday | 5 days | 1 day | Suction drainage
Dietary modifications
| |
|
| Ulíbarb et al. [20] | 1990 | 1 | Supraglottic laryngectomy + L MRND | 6 mg iv Qday | 12 days | 5 days | Suction drainage
Dietary modifications
Pressure dressing
| |
|
| Octreotide |
|
| Ahn et al. [21] | 2012 | 2 | L MRND (1)
Thyroidectomy + R MRND (1) | 100 µg sc Q8–12 | 11 days | 11 days | Suction drainage
Pressure dressing | |
|
| Al-Sebeih et al. [22] | 2001 | 1 | Total laryngectomy + B MRND | 100 µg sc Q8 | Not specified | 3 days | Suction drainage
Dietary modifications
| B chylothoraces requiring chest tubes |
|
| Harlak et al. [23] | 2008 | 1 | R MRND | 100 µg sc Q8 | 15 days | 15 days | Suction drainage
Dietary modifications
Pressure dressing
Surgical exploration w/fibrin glue | Metastatic breast cancer
Reexploration for persistent leak |
|
| Jain et al. [24] | 2015 | 19 | Left neck dissection (19) | 100 µg sc Q8 | Low output 5 days
High output 7 days | Low output 2–4 days
High output 5 days | Suction drainage
Dietary modifications
Pressure dressing | Low output <500 mL/24 hours,
high output >500 mL/24 hours
|
|
| Jiménez et al. [25] | 2008 | 1 | Thyroidectomy + B MRND | 100 µg sc Q8 > somatostatin 6 mg iv Qday | 11 days | N/A | Suction drainage
Dietary modifications
Surgical Exploration
| Right sided chyle leak
Leak resolved with definitive surgical intervention
Switched from octreotide to somatostatin |
|
| El Dabe Mikhail et al. [26] | 2009 | 1 | Thyroidectomy | Not specified | 5 days | 5 days | Dietary modifications
Pressure dressing
| |
|
| Nyquist et al. [27] | 2003 | 1 | Thyroidectomy + L MRND | 100 µg sc Q8 | 8 days | 1 day | Suction drainage
Dietary modifications
Pressure dressing
| |
|
| Ogi et al. [28] | 2013 | 1 | Thyroidectomy + B MRND | 100 µg sc Q12 | 3 days | 3 days | Suction drainage
Dietary modifications
| |
|
| Prabhu and Thomas [29] | 2015 | 1 | L radical neck dissection | 100 µg sc Q8 | 14 days | 14 days | Suction drainage
Dietary modifications
Surgical exploration w/tetracycline | L chylothorax
Side effect: vomiting |
|
| Rodier et al. [30] | 2011 | 1 | Thyroidectomy + central & L MRND (1) | 100 µg sc Q8 | 6 days | 6 days | Suction drainage
Dietary modifications | |
|
| Srikumar et al. [31] | 2006 | 1 | L radical neck dissection | 200 µg sc Qday | 14 days | 14 days | Suction drainage
Dietary modifications | B chylothoraces requiring chest tubes
|
|
| Suver et al. [32] | 2004 | 1 | B MRND + mediastinal dissection | 4 µg/kg/hr | 7 | 7 | Suction drainage
Dietary modifications | Lymphatic malformation in 10-month-old child |
|
| Suslu et al. [33] | 2014 | 3 | Thyroidectomy + L MRND (1) Thyroidectomy + B MRND (1)
Radical neck dissection (1) | 100 µg sc Q8 | 7.5 | 6.5 | Suction drainage
Dietary modifications
Surgical exploration | L chylothorax (1)
Failed surgical exploration (2)
Laterality not specified |
|
| Swanson et al. [34] | 2015 | 12 | L MRND (3)
R MRND (1)
Thyroidectomy + B MRND (3) Thyroidectomy (4)
Parathyroidectomy (1) | 100 µg sc Q8 | 9.4 | 5.5 | Suction drainage
Dietary modifications | |
|
| Touska et al. [35] | 2002 | 1 | R completion thyroid lobectomy | 200 µg sc Q8 | 17 | 10 | Suction drainage
Dietary modifications | No suction drain initially
Reoperation for suspected abscess
Discharged with 7-day course of octreotide |
|
| Valentine et al. [36] | 2002 | 1 | Thyroidectomy + L MRND | 50–100 µg sc Q8 | 24 | 24 | Suction drainage
Dietary modifications
| Octreotide dose increased from 50 ug to 100 µg sc Q8 not effective |
|
| Khurana et al. [37] | 2009 | 1 | Thyroidectomy + B MRND | 100 µg sc Q8 | Not specified | Not specified | Suction drainage
Dietary modifications
Surgical exploration
| B chylothoraces requiring chest tubes
Leak site not identified |
|
