Health-Related Quality of Life and Sleep Quality after 12 Months of Treatment in Nonsevere Obstructive Sleep Apnea: A Randomized Clinical Trial with Continuous Positive Airway Pressure and Mandibular Advancement Splints
Table 2
SF36 domains (norm-based scales) and PSQI global score at baseline and final follow-up (12 months), based on intention-to-treat analysis.
SF36 domains
Baseline
Follow-up
Adj. difference (95% CI)§
§
CPAP (n = 55)
MAS (n = 49)
CPAP (n = 55)
MAS (n = 49)
Physical functioning
48.2 (8.9)
47.5 (8.2)
50.0 (8.4)
48.2 (9.6)
−1.6 (−4.4–1.1)
0.23
Role-physical
49.6 (6.8)
48.6 (8.3)
51.4 (6.3)
49.7 (8.2)
−1.9 (−4.4–0.5)
0.13
Bodily pain
49.2 (11.4)
46.3 (10.1)
50.0 (10.7)
46.8 (11.4)
−1.0 (−4.5–2.5)
0.59
General health
45.4 (9.8)
45.8 (10.6)
48.2 (9.9)
46.9 (10.7)
−1.1 (−4.1–2.0)
0.48
Vitality
42.8 (11.4)
39.8 (10.1)
47.4 (10.8)
47.7 (10.5)
2.0 (−1.9–5.9)
0.32
Social functioning
44.5 (12.4)
42.2 (12.2)
47.5 (12.4)
46.5 (10.2)
0.3 (−4.1–4.6)
0.91
Role-emotional
48.4 (8.1)
48.4 (8.1)
49.5 (8.6)
49.6 (7.4)
0.2 (−2.7–3.0)
0.91
Mental health
47.7 (10.0)
47.8 (11.4)
48.9 (11.7)
50.4 (8.5)
1.9 (−1.8–5.7)
0.30
Physical component score
48.8 (7.6)
47.0 (9.4)
50.5 (8.0)
47.5 (10.4)
−1.8 (−4.1–0.5)
0.13
Mental component score
45.6 (10.3)
44.9 (12.1)
47.8 (12.3)
49.3 (9.2)
2.5 (−1.3–6.3)
0.20
PSQI global score
7.7 (3.5)
8.0 (3.1)
6.6 (2.9)
6.0 (2.6)
−0.8 (−1.8–0.1)
0.09
CPAP: continuous positive airway pressure; MAS: mandibular advancement splint; PSQI: Pittsburgh Sleep Quality Index; SF36: Medical Outcomes Study Short-Form 36-Element Health Survey; SF36 domains and PSQI global score: mean (standard deviation). Statistically significant change from baseline to follow-up within treatment group, paired t-test ().§Difference between MAS and CPAP treatment groups at follow-up, based on linear regression analysis adjusted for baseline variables (age, BMI, sex, smoking, baseline AHI, and the baseline SF36 domain/PSQI global score), reference group: CPAP.
