Health-Related Quality of Life and Sleep Quality after 12 Months of Treatment in Nonsevere Obstructive Sleep Apnea: A Randomized Clinical Trial with Continuous Positive Airway Pressure and Mandibular Advancement Splints

Table 3

SF36 domains (norm-based scales) and PSQI global score at baseline and final follow-up (12 months), based on per-protocol analysis (compliant patients only).

SF36 domains	Baseline		Follow-up		Adj. difference (95% CI)^§	^§
	CPAP (n = 18)	MAS (n = 36)	CPAP (n = 18)	MAS (n = 36)
Physical functioning	47.9 (9.0)	48.3 (7.7)	49.8 (8.3)	49.7 (9.1)	−0.8 (−4.5–2.8)	0.64
Role-physical	49.4 (6.3)	48.4 (9.0)	50.4 (7.2)	50.2 (8.3)	−0.3 (−4.1–3.6)	0.89
Bodily pain	48.4 (12.4)	46.7 (10.3)	47.7 (11.7)	46.9 (11.5)	0.1 (−5.8–6.0)	0.97
General health	45.9 (10.2)	46.9 (10.5)	49.1 (10.5)	49.2 (10.1)	−0.4 (−4.9–4.2)	0.88
Vitality	43.2 (13.7)	39.8 (10.1)	51.0 (9.4)	50.2 (8.4)	0.0 (−5.3–5.2)	0.99
Social functioning	46.6 (12.7)	41.9 (13.0)	51.8 (8.7)	47.7 (9.3)	−1.7 (−6.9–3.5)	0.51
Role-emotional	49.5 (7.3)	48.0 (8.8)	51.3 (6.4)	50.0 (7.4)	0.3 (−3.6–4.1)	0.89
Mental health	49.2 (8.8)	47.2 (12.4)	53.3 (8.1)	51.5 (8.2)	−0.8 (−5.1–3.5)	0.71
Physical component score	47.7 (8.3)	47.9 (9.1)	48.2 (8.7)	48.5 (10.0)	0.0 (−3.6–3.7)	0.99
Mental component score	47.6 (9.6)	44.1 (12.5)	53.2 (4.9)	50.5 (8.0)	−0.2 (−3.9–3.4)	0.91
PSQI global score	7.1 (3.4)	7.7 (3.3)	5.7 (2.3)	5.4 (2.5)	−0.6 (−1.7–0.5)	0.25

CPAP: continuous positive airway pressure; MAS: mandibular advancement splint; PSQI: Pittsburgh Sleep Quality Index SF36: Medical Outcomes Study Short-Form 36-Element Health Survey; SF36 domains and PSQI global score: mean (standard deviation). Statistically significant change from baseline to follow-up within treatment group, paired t-test (). ^§Difference between MAS and CPAP treatment groups at follow-up, based on linear regression analysis adjusted for baseline variables (age, BMI, sex, smoking, baseline AHI, and the baseline SF36 domain/PSQI global score), reference group: CPAP.