Low-Dose UVA Radiation-Induced Adaptive Response in Cultured Human Dermal Fibroblasts

Table 2

Effects of low-dose UVA on fibroblast cell cycle (𝑥±𝑆%, 𝑛=4).

Group/cell cycles	SIG	LDG (J/cm^2)
		7.2^a	14.4^b	28.8^c	57.6^d	115.2^e
G0/G1	83.4 ± 1.01	84.4 ± 0.65	84.6 ± 0.36	84.4 ± 1.59	92.7 ± 0.97^∆	93.9 ± 0.63^∆
S	9.08 ± 0.28	10.7 ± 0.72^∆	12.3 ± 0.91^∆	13.1 ± 1.09^∆	6.30 ± 1.07^∆	4.90 ± 0.65^∆
G2 + M	6.63 ± 0.89	4.18 ± 0.38^∆	2.60 ± 0.55^∆	1.68 ± 0.37^∆	0.73 ± 0.28^∆	0.63 ± 0.22^∆

^▵𝑃<0.01, compared with SIG, proportion of G0/G1 phase, S phase, and G2/M phase of fibroblasts of each LDG differences were extremely significant (𝑡_a were −3.440, 3.280, 𝑡_b were −9.662, 7.319, 𝑡_c were −4.025, 9.316, 𝑡_d were −5.788, 10.78, 23.44, 𝑡_e were −7.461, 10.58, 4.869); linear regression analysis, the cell cycle distribution of the low-dose group were closely related to cumulative doses of UVA irradiation, respectively, 𝑟=0.906, 𝐹=30.68, 𝑃<0.001.
One-way ANOVA, the proportions of respective phases of cell cycle showed no difference among the 7.2 J/cm², 14.4 J/cm², and 28.8 J/cm² dosages, 𝑃>0.05; The 𝑡-test also showed no difference between the dosages of 57.6 J/cm² and 115.2 J/cm², 𝑃>0.05.